{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:42:18Z","timestamp":1760629338014,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T00:00:00Z","timestamp":1376870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>In this study, <jats:sc><jats:italic>N<\/jats:italic><\/jats:sc>\u2010methacryloyl\u2010<jats:sc>l<\/jats:sc>\u2010phenylalanine (MAPA) containing poly(2\u2010hydroxyethylmethacrylate) (HEMA)\u2010based magnetic poly(HEMA\u2013MAPA) nanobeads [mag\u2010poly(HEMA\u2013MAPA)] were radiolabeled with <jats:sup>131<\/jats:sup>I [<jats:sup>131<\/jats:sup>I\u2010mag\u2010poly(HEMA\u2013MAPA)], and the radiopharmaceutical potential of <jats:sup>131<\/jats:sup>I\u2010mag\u2010poly(HEMA\u2013MAPA) was investigated. Quality control studies were carried out by radiochromatographic method to be sure that <jats:sup>131<\/jats:sup>I binded to mag\u2010poly(HEMA\u2013MAPA) efficiently. In this sense, binding yield of <jats:sup>131<\/jats:sup>I\u2010mag\u2010poly(HEMA\u2013MAPA) was found to be about 95\u2013100%. In addition to this, optimum radiodination conditions for <jats:sup>131<\/jats:sup>I\u2010mag\u2010poly(HEMA\u2013MAPA) were determined by thin\u2010layer radiochromatography studies. In addition to thin\u2010layer radiochromatography studies, lipophilicity (partition coefficient) and stability studies for <jats:sup>131<\/jats:sup>I\u2010mag\u2010poly(HEMA\u2013MAPA) were realized. It was determined that lipophilicities of mag\u2010poly(HEMA\u2013MAPA) and <jats:sup>131<\/jats:sup>I\u2010mag\u2010poly(HEMA\u2013MAPA) were 0.12\u2009\u00b1\u20090.01 and 1.79\u2009\u00b1\u20090.76 according to ACD\/log<jats:italic>P<\/jats:italic> algorithm program, respectively. Stability of the radiolabeled compound was investigated in time intervals given as 0, 30, 60, 180, and 1440\u2009min. It was found that <jats:sup>131<\/jats:sup>I\u2010mag\u2010poly(HEMA\u2013MAPA) existed as a stable complex in rat serum within 60\u2009min. After that, biodistribution and scintigraphy studies were carried out by using albino Wistar rats. It was determined that the most important <jats:sup>131<\/jats:sup>I activity uptake was observed in the breast, the ovary, and the pancreas. Scintigraphy studies well supported biodistribution results. 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