{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:42:26Z","timestamp":1790710946701,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>This paper describes a systematic comparative evaluation of five commonly used bifunctional chelators, namely, <jats:italic>p<\/jats:italic>\u2010isothiocyanato benzyl derivatives of diethylenetriaminepentacetic acid (DTPA\u2010NCS), trans\u2010cyclohexyl diethylenetriaminepentacetic acid (CHX\u2010A\u2033\u2010DTPA\u2010NCS), 1,4,7,10\u2010tetraazacyclododecane\u20101,4,7,10\u2010tetraacetic acid (DOTA\u2010NCS), 1,4,7\u2010triazacyclononane\u20101,4,7\u2010triacetic acid (NOTA\u2010NCS), and 3,6,9,15\u2010tetraazabicyclo [9.3.1]pentadeca\u20101(15),11,13\u2010triene\u20103,6,9\u2010triacetic acid (PCTA\u2010NCS), on the basis of their ability to complex <jats:sup>90<\/jats:sup>Y at room temperature, <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> stability and clearance pattern in biological system. The results of the experiments carried out revealed that CHX\u2010A\u2033\u2010DTPA\u2010NCS was the most promising option as it could be radiolabeled with <jats:sup>90<\/jats:sup>Y at room temperature with highest specific activity and demonstrated high <jats:italic>in vitro<\/jats:italic> stability in human serum and in presence of challenging metal ions commonly present in human plasma. The clearance pattern in Swiss mice revealed that <jats:sup>90<\/jats:sup>Y\u2010CHX\u2010 A\u2033\u2010DTPA\u2010NCS cleared through the kidneys with minimum retention in any other major organ. Thus, the use of cyclohexyl\u2010DTPA based bifunctional chelators would increase the scope of making <jats:sup>90<\/jats:sup>Y\u2010labeled agents suitable for targeted therapy.<\/jats:p>","DOI":"10.1002\/jlcr.3140","type":"journal-article","created":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T01:11:22Z","timestamp":1385428282000},"page":"65-74","source":"Crossref","is-referenced-by-count":22,"title":["A systematic comparative evaluation of <sup>90<\/sup>Y\u2010labeled bifunctional chelators for their use in targeted therapy"],"prefix":"10.1002","volume":"57","author":[{"given":"Rubel","family":"Chakravarty","sequence":"first","affiliation":[{"name":"Isotope Applications and Radiopharmaceuticals Division Bhabha Atomic Research Centre  Trombay Mumbai 400 085 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Isotope Applications and Radiopharmaceuticals Division Bhabha Atomic Research Centre  Trombay Mumbai 400 085 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Dash","sequence":"additional","affiliation":[{"name":"Isotope Applications and Radiopharmaceuticals Division Bhabha Atomic Research Centre  Trombay Mumbai 400 085 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc41554f"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874471011205030253"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2012.1285"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481201900304"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2147\/CMAR.S6765","volume":"2","author":"Emmanouilides C.","year":"2009","journal-title":"Cancer Manage. 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