{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:56:04Z","timestamp":1790765764625,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Carbon\u201014 labeled linker molecule, <jats:italic>N<\/jats:italic>\u2010succinimidyl\u20103\u2010maleimidopropionate was prepared for disposition studies of PEGylated biologics. Our new route started with 100\u2009mCi of carbon\u201014 labeled Potassium cyanide (KCN) to prepare 55\u2009mCi of [1\u2010<jats:sup>14<\/jats:sup>C]<jats:italic>N<\/jats:italic>\u2010succinimidyl\u20103\u2010maleimidopropionate, 6 in five steps. This represents a multiple of 5.5\u00d7 improvement in the yield of the desired labeled product compared with our previous synthesis.<\/jats:p>","DOI":"10.1002\/jlcr.3225","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T04:03:31Z","timestamp":1412913811000},"page":"667-669","source":"Crossref","is-referenced-by-count":2,"title":["The synthesis of <sup>14<\/sup>C\u2010labeled <i>N<\/i>\u2010succinimidyl\u20103\u2010maleimidopropionate, a linker molecule for PEGylated biologics"],"prefix":"10.1002","volume":"57","author":[{"given":"Kai","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Chemical Synthesis, Radiochemistry Group, Discovery Chemistry Bristol\u2010Myers Squibb Pharmaceutical Research and Development  P.O. Box\u20094000 Princeton NJ 08543 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad D.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Department of Chemical Synthesis, Radiochemistry Group, Discovery Chemistry Bristol\u2010Myers Squibb Pharmaceutical Research and Development  P.O. Box\u20094000 Princeton NJ 08543 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Bonacorsi","sequence":"additional","affiliation":[{"name":"Department of Chemical Synthesis, Radiochemistry Group, Discovery Chemistry Bristol\u2010Myers Squibb Pharmaceutical Research and Development  P.O. Box\u20094000 Princeton NJ 08543 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3077"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.044792"},{"key":"e_1_2_7_4_1","first-page":"242","volume":"11","author":"Gaberc\u2010Porekar V.","year":"2008","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200900218"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240802650568"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)81792-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc050102k"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc070083"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlcr.3225","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.3225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:04:29Z","timestamp":1760623469000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.3225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/jlcr.3225"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.3225","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10]]}}}