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The use of a microwave as a source of heat energy can allow chemical reactions to proceed over much shorter reaction times and in higher yields than they would do under conventional thermal conditions. A microwave reactor developed by Resonance Instrument Inc. (Model 520\/521) and CEM (PETWave) has been used exclusively for the synthesis of radiolabeled agents for positron emission tomography by numerous groups throughout the world. In this study, we have developed a novel resonant\u2010type microwave reactor powered by a solid\u2010state device and confirmed that this system can focus microwave power on a small amount of reaction solution. Furthermore, we have demonstrated the rapid and facile radiosynthesis of 16<jats:italic>\u03b1<\/jats:italic>\u2010[<jats:sup>18<\/jats:sup>F]fluoroestradiol, 4\u2010[<jats:sup>18<\/jats:sup>F]fluoro\u2010<jats:italic>N<\/jats:italic>\u2010[2\u2010(1\u2010methoxyphenyl)\u20101\u2010piperazinyl]ethyl\u2010<jats:italic>N<\/jats:italic>\u20102\u2010pyridinylbenzamide, and <jats:italic>N<\/jats:italic>\u2010succinimidyl 4\u2010[<jats:sup>18<\/jats:sup>F]fluorobenzoate using our newly developed microwave reactor.<\/jats:p>","DOI":"10.1002\/jlcr.3232","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T03:45:24Z","timestamp":1412739924000},"page":"680-686","source":"Crossref","is-referenced-by-count":12,"title":["Development of a resonant\u2010type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals"],"prefix":"10.1002","volume":"57","author":[{"given":"Hiroyuki","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Patho\u2010Functional Bioanalysis, Graduate School of Pharmaceutical Sciences Kyoto University  Sakyo\u2010ku Kyoto Kyoto 606\u20108501 Japan"},{"name":"Radioisotope Research Center Kyoto University  Yoshida Konoe\u2010cho, Sakyo\u2010ku Kyoto Kyoto 606\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Patho\u2010Functional Bioanalysis, Graduate School of Pharmaceutical Sciences Kyoto University  Sakyo\u2010ku Kyoto Kyoto 606\u20108501 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Ohneda","sequence":"additional","affiliation":[{"name":"Technology Development Dept. 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