{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:31:32Z","timestamp":1791318692813,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T00:00:00Z","timestamp":1438646400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BPI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>The <jats:sup>68<\/jats:sup>Ge\/<jats:sup>68<\/jats:sup>Ga generator is of increasing interest for clinical PET. For successful labelling, the eluate has to be purified. The aim of our approach is to improve the existing anionic methods which have a number of advantages compared to other methods but which use high concentrated HCl, and require an additional anionizing step. A new <jats:sup>68<\/jats:sup>Ga\u2010eluate anionic purification method that enables rapid and high efficiency labelling of DOTA and NODAGA conjugated peptides in high radiochemical purity is described. The new method uses NaCl as an alternative Cl<jats:sup>\u2212<\/jats:sup> source to the corrosive HCl and combines the three standard steps in a single step. The recovery yield was \u226590%, and the <jats:sup>68<\/jats:sup>Ge breakthrough was in conformity with the European Pharmacopeia limit. An automated labelling of DOTA and NODAGA\u2010conjugated peptides was performed with the new method, using acetate sodium buffer, with a total duration of 13\u2009min and a radiochemical yield &gt;85%. The labelled peptides have a radiochemical purity exceeding 99% and can be used directly without any further purification step and without the quality control by gas chromatography. Furthermore, the new method has an economic advantage: it offers the possibility to use generator until 20\u2009months after the calibration date.<\/jats:p>","DOI":"10.1002\/jlcr.3316","type":"journal-article","created":{"date-parts":[[2015,8,4]],"date-time":"2015-08-04T04:18:52Z","timestamp":1438661932000},"page":"403-410","source":"Crossref","is-referenced-by-count":8,"title":["A new <sup>68<\/sup>Ga anionic concentration and purification method for automated synthesis of [<sup>68<\/sup>Ga]\u2010DOTA or NODAGA conjugated peptides in high radiochemical purity"],"prefix":"10.1002","volume":"58","author":[{"given":"Rana","family":"Ben Azzouna","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department and DHU FIRE Bichat\u2010Claude Bernard University Hospital, AP\u2010HP  Paris France"},{"name":"UMR 1148 Inserm  Paris France"},{"name":"Federation de Recherche en Imagerie Multimodale Paris 7 University  Paris France"},{"name":"Pharmacy Department Bichat Claude Bernard University Hospital, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Alshoukr","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department and DHU FIRE Bichat\u2010Claude Bernard University Hospital, AP\u2010HP  Paris France"},{"name":"UMR 1148 Inserm  Paris France"},{"name":"Federation de Recherche en Imagerie Multimodale Paris 7 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Leygnac","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department and DHU FIRE Bichat\u2010Claude Bernard University Hospital, AP\u2010HP  Paris France"},{"name":"UMR 1148 Inserm  Paris France"},{"name":"Federation de Recherche en Imagerie Multimodale Paris 7 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Guez","sequence":"additional","affiliation":[{"name":"Pierre et Marie Curie University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Guerbet, Research Center  Aulnay\u2010sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rousseaux","sequence":"additional","affiliation":[{"name":"Guerbet, Research Center  Aulnay\u2010sous\u2010Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Guilloteau","sequence":"additional","affiliation":[{"name":"Inserm, U930, Fran\u00e7ois Rabelais University CHRU  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Le Guludec","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department and DHU FIRE Bichat\u2010Claude Bernard University Hospital, AP\u2010HP  Paris France"},{"name":"UMR 1148 Inserm  Paris France"},{"name":"Federation de Recherche en Imagerie Multimodale Paris 7 University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc030078f"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-27994-2_5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.7447"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2012.10.012"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.232"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1702-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2010.11.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.035667"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2008.04.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2009.10.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.040378"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874471011306020002"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-9140(88)80032-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc300103t"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.070953"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-004-1486-0"},{"key":"e_1_2_6_18_1","first-page":"77","volume":"10","author":"M\u00fcller D.","year":"2011","journal-title":"World J. Nucl. Med."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2012.08.011"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-708X(81)90174-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp900106m"},{"issue":"3","key":"e_1_2_6_22_1","first-page":"508","volume":"23","author":"Pharmacopeia E.","year":"2011","journal-title":"Gallium (68Ga) Chlor. Sol. Radiolabelling. Monograph. N\u00b0 2464"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2012.03.032"},{"issue":"2","key":"e_1_2_6_24_1","first-page":"310","volume":"23","author":"Pharmacopeia E.","year":"2011","journal-title":"Gallium (68Ga) Edotreotide Inject. Monograph. N\u00b0 2482."}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlcr.3316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.3316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:16:39Z","timestamp":1760631399000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.3316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/jlcr.3316"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.3316","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}