{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:17:29Z","timestamp":1789877849341,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Noninvasive brain imaging is a process that allows scientists and physicians to view and monitor the areas of the brain. The aim of this study was to formulate a novel radiopharmaceutical for the detection of brain disorders at early stages in susceptible patients. <jats:sup>99m<\/jats:sup>Tc\u2013ropinirole was prepared by the direct complexation of ropinirole with technetium\u201099m. The results showed that the radiochemical yield <jats:sup>99m<\/jats:sup>Tc\u2013ropinirole was 92\u2009\u00b1\u20092.87% and the radiochemical yield was evaluated by paper chromatography and HPLC.<\/jats:p><jats:p><jats:italic>In vitro<\/jats:italic> studies showed that the formed complex was stable for up to 6\u2009h. <jats:italic>In vivo<\/jats:italic> uptake of <jats:sup>99m<\/jats:sup>Tc\u2013ropinirole in the brain was 4.87\u2009\u00b1\u20090.15% injected dose\/g organ at 30\u2009min post\u2010injection, which cleared from the brain with time till it reaches 2.3% at 2\u2009h post\u2010injection indicating that the brain uptake of <jats:sup>99m<\/jats:sup>Tc\u2013ropinirole is higher than that of the commercially available <jats:sup>99m<\/jats:sup>Tc\u2010HMPAO, which is 2.25% at 30\u2009min. Pre\u2010dosing mice with cold ropinirole reduced the brain uptake to 0.26\u2009\u00b1\u20090.01% injected dose\/g organ, so this confirms the high specificity and selectivity of this radiotracer for the assessment of the dopamine receptors.<\/jats:p>","DOI":"10.1002\/jlcr.3380","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T22:24:29Z","timestamp":1456439069000},"page":"147-152","source":"Crossref","is-referenced-by-count":16,"title":["Preparation and biological evaluation of <sup>99m<\/sup>Tc\u2013ropinirole as a novel radiopharmaceutical for brain imaging"],"prefix":"10.1002","volume":"59","author":[{"given":"M. A.","family":"Motaleb","sequence":"first","affiliation":[{"name":"Hot Labs Center Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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