{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:05:44Z","timestamp":1771063544896,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:00:00Z","timestamp":1457481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>This study aimed to provide an easy method for synthesis of 1\u2010hydroxy\u20102\u2010(3\u2010pyridyl) ethylidene bisphosphonic acid monosodium (sod. risedronate) with a high yield of 71%. The synthesized risedronate was labeled with technetium\u201099\u2009m using two different reducing agents (SnCl<jats:sub>2<\/jats:sub>.2H<jats:sub>2<\/jats:sub>O and NaBH<jats:sub>4<\/jats:sub>) where NaBH<jats:sub>4<\/jats:sub> gave stable complex and higher radiochemical yield more than SnCl<jats:sub>2<\/jats:sub>.2H<jats:sub>2<\/jats:sub>O. The results showed that, the radiochemical purity of <jats:sup>99m<\/jats:sup>Tc(NaBH<jats:sub>4<\/jats:sub>)\u2010risedronate was 99.2\u2009\u00b1\u20090.6% and its stability was up to 6\u2009h. Biodistribution study showed high uptake and long retention of <jats:sup>99m<\/jats:sup>Tc(NaBH<jats:sub>4<\/jats:sub>)\u2010risedronate in bone starting from 15\u2009min (29\u2009\u00b1\u20092.5% ID\/organ) up to 4\u2009h (35.1\u2009\u00b1\u20093.2 ID\/organ) post injection. This research could introduce an easy and effective method for synthesis and labeling of risedrionate and affording a good tracer for bone imaging.<\/jats:p>","DOI":"10.1002\/jlcr.3384","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T00:48:23Z","timestamp":1457484503000},"page":"157-163","source":"Crossref","is-referenced-by-count":49,"title":["An easy and effective method for synthesis and radiolabelling of risedronate as a model for bone imaging"],"prefix":"10.1002","volume":"59","author":[{"given":"M. A.","family":"Motaleb","sequence":"first","affiliation":[{"name":"Labeled Compounds Department, Hot Laboratories Center Atomic Energy Authority  P.O. Box\u00a013759 Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S. A.","family":"Adli","sequence":"additional","affiliation":[{"name":"Labeled Compounds Department, Hot Laboratories Center Atomic Energy Authority  P.O. 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