{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T04:09:16Z","timestamp":1769314156378,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004167","name":"Medicines for Malaria Venture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004167","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology, Government of Kerala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>The antimalarial compound MMV390048 (<jats:bold>[<\/jats:bold><jats:sup><jats:bold>14<\/jats:bold><\/jats:sup><jats:bold>C<\/jats:bold><jats:bold>]\u201011<\/jats:bold>) was labeled with carbon\u201014 isotope via a 3\u2010step synthesis. It was obtained in a 15.5% radiochemical overall yield from carbon\u201014 labeled methyl iodide with a radiochemical purity of &gt;99%. After single oral administration of <jats:bold>[<\/jats:bold><jats:sup><jats:bold>14<\/jats:bold><\/jats:sup><jats:bold>C<\/jats:bold><jats:bold>]\u201011<\/jats:bold> to albino and pigmented rats its tissue distribution profile was studied. Tissue distribution results showed high local exposure in the GI tract and excretory organs but low exposure of all other tissues. The radioactivity uptake was higher in the eyes of the pigmented rats than in the eyes of the albino rats at all\u2010time points. The highest accumulation reached in the eyes of the pigmented rats was 0.46% at 6\u00a0hours. However, these levels are still very low as compared to the other organs studied. There was very little radioactivity from MMV390048 (<jats:bold>[<\/jats:bold><jats:sup><jats:bold>14<\/jats:bold><\/jats:sup><jats:bold>C<\/jats:bold><jats:bold>]\u201011<\/jats:bold>) present in the skin of both the albino and pigmented rats. The results obtained are supportive of further development of MMV390048 as a potential antimalarial compound.<\/jats:p>","DOI":"10.1002\/jlcr.3445","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T03:46:54Z","timestamp":1474343214000},"page":"680-688","source":"Crossref","is-referenced-by-count":5,"title":["Carbon\u201014 radiolabeling and tissue distribution evaluation of MMV390048"],"prefix":"10.1002","volume":"59","author":[{"given":"Molahlehi S.","family":"Sonopo","sequence":"first","affiliation":[{"name":"Radiochemistry Necsa  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adushan","family":"Pillay","sequence":"additional","affiliation":[{"name":"Radiochemistry Necsa  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Chibale","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Centre (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry University of Cape Town  Rondebosch South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana","family":"Marjanovic\u2010Painter","sequence":"additional","affiliation":[{"name":"Radiochemistry Necsa  Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Donini","sequence":"additional","affiliation":[{"name":"Translational Medicine MMV  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan R.","family":"Zeevaart","sequence":"additional","affiliation":[{"name":"DST\/NWU, Preclinical Drug Development Platform North\u2010West University  Potchefstroom South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health organization: World Malaria 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