{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:11:47Z","timestamp":1790503907359,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T00:00:00Z","timestamp":1478995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An improved high yielding radiosynthesis of the known thiol\u2010reactive maleimide\u2010containing prosthetic group1\u2010[3\u2010(2\u2010[<jats:sup>18<\/jats:sup>F]fluoropyridine\u20103\u2010yloxy)propyl]pyrrole\u20102,5\u2010dione ([<jats:sup>18<\/jats:sup>F]FPyME) is described. The target compound was obtained by a two\u2010step one\u2010pot procedure starting from a maleimide\u2010containing nitro\u2010precursor that was protected as a Diels\u2010Alder adduct with 2,5\u2010dimethylfurane. Nucleophilic radiofluorination followed by heat induced deprotection through a Retro Diels Alder reaction yielded, after chromatographic isolation, [<jats:sup>18<\/jats:sup>F]FPyME with a radiochemical yield of 20% in about 60 min overall synthesis time. A variety of other [<jats:sup>18<\/jats:sup>F]fluoropyridine based maleimide\u2010containing prosthetic groups should be accessible via the described synthetic strategy.<\/jats:p>","DOI":"10.1002\/jlcr.3469","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T11:12:53Z","timestamp":1479294773000},"page":"87-92","source":"Crossref","is-referenced-by-count":8,"title":["Efficient synthesis of [<sup>18<\/sup>F]FPyME: A new approach for the preparation of maleimide\u2010containing prosthetic groups for the conjugation with thiols"],"prefix":"10.1002","volume":"60","author":[{"given":"Melanie","family":"Cavani","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and Medicine INM\u20105: Nuclear Chemistry Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Bier","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine INM\u20105: Nuclear Chemistry Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Holschbach","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine INM\u20105: Nuclear Chemistry Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz H.","family":"Coenen","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine INM\u20105: Nuclear Chemistry Forschungszentrum J\u00fclich  J\u00fclich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2006.09.009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580230502"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc0497463"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2010.09.023"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2011.03.043"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01132a042"},{"key":"e_1_2_6_8_1","article-title":"5\u2010Alkoxy tryptamine derivatives","author":"Meng Q","year":"1997","journal-title":"Patent"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.25802601127"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc8000112"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlcr.3469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.3469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:30:06Z","timestamp":1760635806000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.3469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,13]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/jlcr.3469"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.3469","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,13]]}}}