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The synthesis of nitrile <jats:bold>[<\/jats:bold><jats:sup><jats:bold>14<\/jats:bold><\/jats:sup><jats:bold>C]\u20101<\/jats:bold> was completed in 3 steps from C\u201014 labeled 4\u2010bromobenzonitrile in accord with the previously developed medicinal chemistry route. The second compound, <jats:bold>2<\/jats:bold>, did not possess an arylnitrile as did <jats:bold>1<\/jats:bold>, which made the synthetic design more complex. An advanced, unlabeled benzotriazole containing intermediate, <jats:bold>10<\/jats:bold>, was synthesized in low yield over 3 steps and was subsequently reacted with K<jats:sup>14<\/jats:sup>CN to give a mixture of diastereomers <jats:bold>12<\/jats:bold>. Separation of the diastereomers followed by deprotection afforded <jats:bold>[<\/jats:bold><jats:sup><jats:bold>14<\/jats:bold><\/jats:sup><jats:bold>C]\u20102<\/jats:bold> in a 13% radiochemical yield.<\/jats:p>","DOI":"10.1002\/jlcr.3502","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T06:57:25Z","timestamp":1490165845000},"page":"294-301","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of 2 C\u201014 labeled cathepsin C inhibitors: The use of a cyanide to displace a <scp>Benzotriazole<\/scp>"],"prefix":"10.1002","volume":"60","author":[{"given":"Lee","family":"Kingston","sequence":"first","affiliation":[{"name":"Isotope Chemistry, Pharmaceutical Sciences iMED AstraZeneca Pharmaceuticals AB  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Bergare","sequence":"additional","affiliation":[{"name":"Isotope Chemistry, Pharmaceutical Sciences iMED AstraZeneca Pharmaceuticals AB  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"L\u00f6nn","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Respiratory, Inflammation, and Autoimmune iMED AstraZeneca Pharmaceuticals AB  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Ericsson","sequence":"additional","affiliation":[{"name":"Isotope Chemistry, Pharmaceutical Sciences iMED AstraZeneca Pharmaceuticals AB  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Gr\u00f6nberg","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Respiratory, Inflammation, and Autoimmune iMED AstraZeneca Pharmaceuticals AB  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Chen","sequence":"additional","affiliation":[{"name":"Pharmaron Beijing Co., Ltd.  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