{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:33:20Z","timestamp":1760661200895,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["2017MS044"],"award-info":[{"award-number":["2017MS044"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11575211"],"award-info":[{"award-number":["11575211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Melphalan (MFL) is a typical nitrogen mustard for the treatment of many types of cancer. For the purpose to develop novel <jats:sup>99m<\/jats:sup>Tc\u2010labeled tumor imaging agents with SPECT, MFL was directly labeled by <jats:sup>99m<\/jats:sup>Tc using diethylene triamine pentacetate acid (DTPA) as bifunctional chelating agent. The novel ligands were successfully synthesized by conjugation of DTPA to MFL to get monosubstituted DTPA\u2010MFL and bis\u2010substituted DTPA\u20102MFL. Radiolabeling was performed in high yield to get <jats:sup>99m<\/jats:sup>Tc\u2010DTPA\u2010MFL and <jats:sup>99m<\/jats:sup>Tc\u2010DTPA\u20102MFL, respectively, which were hydrophilic and stable at room temperature. The high initial tumor uptake with retention, good tumor\/muscle ratios, and satisfactory scintigraphic images suggested the potential of <jats:sup>99m<\/jats:sup>Tc\u2010DTPA\u2010MFL and <jats:sup>99m<\/jats:sup>Tc\u2010DTPA\u20102MFL for tumor imaging. However, the slow normal tissue clearance would be a great obstacle. Further modification on the linker and\/or <jats:sup>99m<\/jats:sup>Tc\u2010chelate to improve the tumor targeting efficacy and in vivo kinetic profiles is currently in progress.<\/jats:p>","DOI":"10.1002\/jlcr.3575","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T20:22:36Z","timestamp":1507753356000},"page":"659-665","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis, <sup>99m<\/sup>Tc\u2010labeling, and preliminary biological evaluation of <scp>DTPA<\/scp>\u2010melphalan conjugates"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2981-6129","authenticated-orcid":false,"given":"Jianjun","family":"Wang","sequence":"first","affiliation":[{"name":"College of Environmental Science and Engineering North China Electric Power University  Beijing China"},{"name":"Division of Nuclear Technology and Applications, Institute of High Energy Physics Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nuclear Technology and Applications, Institute of High Energy Physics Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinquan","family":"Xue","sequence":"additional","affiliation":[{"name":"Division of Nuclear Technology and Applications, Institute of High Energy Physics Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nuclear Technology and Applications, Institute of High Energy Physics Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nuclear Technology and Applications, Institute of High Energy Physics Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200203000-00002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx00044a018"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc749"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2009.02.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-010-0702-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.10.062"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3481"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.1698"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-016-4955-6"},{"issue":"99","key":"e_1_2_6_11_1","first-page":"2205","article-title":"Potential technetium small molecule radiopharmaceuticals","volume":"199","author":"Jurisson SS","journal-title":"Chem Rev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.133447"},{"issue":"3","key":"e_1_2_6_13_1","first-page":"181","article-title":"Analysis of renal handling of radiopharmaceuticals","volume":"46","author":"Trejtnar F","year":"2002","journal-title":"Q J Nucl Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000045268"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-015-4308-x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-014-3038-9"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjlcr.3575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.3575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:59:56Z","timestamp":1760637596000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.3575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":15,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/jlcr.3575"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.3575","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"type":"print","value":"0362-4803"},{"type":"electronic","value":"1099-1344"}],"subject":[],"published":{"date-parts":[[2017,11,20]]}}}