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To assess the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/en.wikipedia.org\/wiki\/Pharmacokinetics\">pharmacokinetic<\/jats:ext-link> properties, C\u201014 labeled ketamine and norketamine were prepared separately from commercially available [<jats:sup>14<\/jats:sup>C]CuCN through a five\u2010step sequence with the C\u201014 label at the quaternary carbon of the cyclohexyl ring. Chiral resolution of [<jats:sup>14<\/jats:sup>C]ketamine and chiral column separation of [<jats:sup>14<\/jats:sup>C]norketamine resolved\/separated the (<jats:italic>S<\/jats:italic>)\u2010enantiomers from (<jats:italic>R<\/jats:italic>)\u2010enantiomers.<\/jats:p>","DOI":"10.1002\/jlcr.3669","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T02:39:06Z","timestamp":1531276746000},"page":"864-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis of carbon\u201014 labeled ketamine and norketamine"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-3778","authenticated-orcid":false,"given":"Lu","family":"Chen","sequence":"first","affiliation":[{"name":"Isotope Chemistry and Biotransformations, Janssen Research &amp; Development Johnson &amp; Johnson  Spring House Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gong","sequence":"additional","affiliation":[{"name":"Isotope Chemistry and Biotransformations, Janssen Research &amp; 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