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Click chemistry, and more particularly cycloadditions, is an interesting approach to radiolabel molecules thanks to mild reaction conditions, high yields, low by\u2010products formation, and strong orthogonality. Moreover, the chemical functions involved in the cycloaddition reaction are stable in the drastic radiofluorination conditions, thus allowing a simple radiosynthetic route to prepare the prosthetic reagent. We report herein the radiosynthesis of <jats:sup>18<\/jats:sup>F\u2010FPyZIDE, a pyridine\u2010based azide\u2010bearing prosthetic reagent. 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