{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:43:54Z","timestamp":1783471434812,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Copper\u2010mediated radiofluorination provides a quick and versatile approach for <jats:sup>18<\/jats:sup>F\u2010labeling of arenes and heteroarenes. However, this method is known to be base sensitive, which has been a barrier for preparative scale radiosynthesis. In this report, we provide an approach for copper\u2010mediated radiofluorination without azeotropic drying or adding a base. [<jats:sup>18<\/jats:sup>F]Fluoride trapped on a PS\u2010HCO<jats:sub>3<\/jats:sub> Sep\u2010Pak was quantitatively eluted with a solution of 4\u2010dimethylaminopyridinium trifluoromethanesulfonate (DMAP\u00b7OTf) in anhydrous <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylformamide (DMF). The eluted solution was directly used for copper\u2010mediated radiofluorination. Twelve boronic ester substrates were tested, yielding fluorinated products in 27% to 83% radiochemical yield based on HPLC analysis. This approach was successfully applied to the radiosynthesis of [<jats:sup>18<\/jats:sup>F]flumazenil, a well\u2010known positron emission tomography (PET) tracer for imaging central benzodiazepine receptors, with a radiochemical yield of 47%. This highly efficient protocol significantly augments the powerful copper\u2010mediated radiofluorination approach.<\/jats:p>","DOI":"10.1002\/jlcr.3705","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T07:14:00Z","timestamp":1547536440000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["An azeotropic drying\u2010free approach for copper\u2010mediated radiofluorination without addition of base"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5234-9410","authenticated-orcid":false,"given":"Xiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Imaging Probe Development Center National Heart, Lung, and Blood Institute, National Institutes of Health  Rockville 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