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Radiochemical yield was 6 \u00b1 1.5% (n = 9), and radiochemical purity was over 99%. The molar activity was 0.44 to 0.76 GBq\/\u03bcmol. [<jats:sup>18<\/jats:sup>F]CF<jats:sub>3<\/jats:sub>\u2010<jats:sc>l<\/jats:sc>\u2010Trp was stable for up to 6 hours in mouse and human sera at 37\u00b0C. Protein\u2010binding was 0.26 \u00b1 0.03% and 0.34 \u00b1 0.02% in human and mouse serum at 60 minutes, respectively. In conclusion, enantiopure [<jats:sup>18<\/jats:sup>F]CF<jats:sub>3<\/jats:sub>\u2010<jats:sc>l<\/jats:sc>\u2010Trp was synthesized as a feasible imaging agent for the serotonergic system.<\/jats:p>","DOI":"10.1002\/jlcr.3772","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T04:59:50Z","timestamp":1559019590000},"page":"566-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design and synthesis of enantiopure <sup>18<\/sup>F\u2010labelled [<sup>18<\/sup>F]trifluoromethyltryptophan from 2\u2010halotryptophan derivatives via copper(I)\u2010mediated [<sup>18<\/sup>F]trifluoromethylation and evaluation of its in vitro characterization for the serotonergic system imaging"],"prefix":"10.1002","volume":"62","author":[{"given":"Ho Young","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Institute of Radiation Medicine Seoul National University 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