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Conventionally, Water\u2010<jats:sup>18<\/jats:sup>O has been separated from other stable oxygen isotope species (<jats:sup>16<\/jats:sup>O, <jats:sup>17<\/jats:sup>O) by water distillation or nitric oxide distillation. However, conventional methods are costly and may have safety issues. In 2004, we developed the first unit of our novel oxygen isotope separation process by cryogenic oxygen distillation to overcome these issues. To meet the needs of the market, we built a second unit in 2013 and a third in 2016. 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