{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:24:51Z","timestamp":1790771091668,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K08061"],"award-info":[{"award-number":["JP20K08061"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2021,6,30]]},"abstract":"<jats:p>\n                    A copper\u2010mediated radioiodination using aryl boronic precursors is attracting attention as a solution to oxidative iododestannylation and nickel\u2010mediated radioiodination drawbacks. The copper\u2010mediated radiolabeling method allows radioiodination at room temperature with stable aryl boronic precursors without preparing complex starting materials or reagents and can be performed in a reaction vessel exposed to air. This method has good potential in radiochemistry; however, studies on the scope of copper\u2010mediated radioiodination through boronic precursors are insufficient. In particular, few reports have demonstrated the effect of protecting groups on radiolabeling efficiency. Therefore, the effect of the protecting group of aryl boronic acids on the copper\u2010mediated radioiodination was investigated. In addition, this method, which does not require heating, is expected to be useful for direct radiolabeling of peptides. Thus, we attempted direct radioiodination of c(RGDyk) as an example. The resulting radioiodination method was well tolerated in various substrates and was unaffected by the pinacol ester\u2010type protecting group. Also, c(RGDyk) was labeled with\n                    <jats:sup>125<\/jats:sup>\n                    I via copper\u2010mediated radioiodination using an aryl boronic acid precursor. The reaction time and yield were improved, compared with the indirect method. Furthermore, the large difference in polarity between the boronic acid precursor and the radiolabeled compound facilitated purification.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.3925","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T22:44:40Z","timestamp":1621032280000},"page":"336-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Copper\u2010mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide"],"prefix":"10.1002","volume":"64","author":[{"given":"Yuto","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry Kyoto Pharmaceutical University  Kyoto 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Medical Science Kyoto College of Medical Science  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunao","family":"Hattori","sequence":"additional","affiliation":[{"name":"Center for Instrumental Analysis Kyoto Pharmaceutical University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Radioisotope Research Center Kyoto Pharmaceutical University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry Kyoto Pharmaceutical University  Kyoto 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