{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:00:01Z","timestamp":1773388801641,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016M2A2A7A03913537"],"award-info":[{"award-number":["2016M2A2A7A03913537"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["731.015.413"],"award-info":[{"award-number":["731.015.413"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>The trifluoromethyl group is a prominent motif in biologically active compounds and therefore of great interest for the labeling with the positron emitter fluorine\u201018 for positron emission tomography (PET) imaging. Multiple labeling strategies have been explored in the past; however, most of them suffer from low molar activity due to precursor degradation. In this study, the potential of 1\u2010(difluoromethyl)\u20103\u2010methyl\u20104\u2010phenyl\u20101<jats:italic>H<\/jats:italic>\u20101,2,3\u2010triazol\u20103\u2010ium triflate as precursor for the synthesis of the [<jats:sup>18<\/jats:sup>F]trifluoromethylation building block [<jats:sup>18<\/jats:sup>F]fluoroform with high molar activity was investigated. The triazolium precursor was reacted under various conditions with [<jats:sup>18<\/jats:sup>F]fluoride, providing [<jats:sup>18<\/jats:sup>F]fluoroform with radiochemical yields (RCY) and molar activities (<jats:italic>A<\/jats:italic><jats:sub><jats:italic>m<\/jats:italic><\/jats:sub>) comparable and even superior with already existing methods. Highest molar activities (<jats:italic>A<\/jats:italic><jats:sub><jats:italic>m<\/jats:italic><\/jats:sub>\u2009=\u2009153\u2009\u00b1\u200914\u2009GBq\/\u03bcmol, dc, EOS) were observed for the automated procedure on the Neptis\u00ae perform module. Due to its easy handling and good RCY and <jats:italic>A<\/jats:italic><jats:sub><jats:italic>m<\/jats:italic><\/jats:sub> in the [<jats:sup>18<\/jats:sup>F]fluoroform synthesis, the triazolium precursor is a valuable alternative to already known precursors.<\/jats:p>","DOI":"10.1002\/jlcr.3939","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T20:10:04Z","timestamp":1628712604000},"page":"466-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating <i>N<\/i>\u2010difluoromethyltriazolium triflate as a precursor for the synthesis of high molar activity [<sup>18<\/sup>F]fluoroform"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-3358","authenticated-orcid":false,"given":"Anna","family":"Pees","sequence":"first","affiliation":[{"name":"Amsterdam UMC, Radiology and Nuclear Medicine, Radionuclide Center VU University  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J. 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