{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:35:02Z","timestamp":1787495702646,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2022,5,15]]},"abstract":"<jats:p>\n                    We have developed 8\u2010amino\u20103\u2010(2\n                    <jats:italic>S<\/jats:italic>\n                    ,5\n                    <jats:italic>R<\/jats:italic>\n                    \u2010dimethyl\u20101\u2010piperidyl)\u2010[1,2,4]triazolo[4,3\u2010\n                    <jats:italic>a<\/jats:italic>\n                    ]pyrazine\u20105\u2010[\n                    <jats:sup>11<\/jats:sup>\n                    C]carbonitrile ([\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38) as a positron emission tomography (PET) tracer for the imaging of phosphodiesterase 7. For the fully automated production of [\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38 routinely and efficiently for clinical applications, we determined the radiosynthesis procedure of [\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38 using [\n                    <jats:sup>11<\/jats:sup>\n                    C]hydrogen cyanide ([\n                    <jats:sup>11<\/jats:sup>\n                    C]HCN) as a PET radiopharmaceutical. Radiosynthesis of [\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38 was performed using an automated\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010labeling synthesizer developed in\u2010house within 40\u2009min after the end of irradiation. [\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38 was obtained with a relatively high radiochemical yield (33\u2009\u00b1\u20095.5% based on [\n                    <jats:sup>11<\/jats:sup>\n                    C]CO\n                    <jats:sub>2<\/jats:sub>\n                    at the end of irradiation, decay\u2010corrected,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915), radiochemical purity (&gt;97%,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915), and molar activity (47\u2009\u00b1\u200912\u2009GBq\/\u03bcmol at the end of synthesis,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915). All the results of the quality control (QC) testing for the [\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38 injection complied with our in\u2010house QC and quality assurance specifications. We successfully automated the radiosynthesis of [\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38 for clinical applications using an\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010labeling synthesizer and sterile isolator. Taken together, this protocol provides a new radiopharmaceutical [\n                    <jats:sup>11<\/jats:sup>\n                    C]MTP38 suitable for clinical applications.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.3965","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T21:13:09Z","timestamp":1644009189000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Automated radiosynthesis of [\n                    <sup>11<\/sup>\n                    C]MTP38\u2014a phosphodiesterase 7 imaging tracer\u2014using [\n                    <sup>11<\/sup>\n                    C]hydrogen cyanide for clinical applications"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-678X","authenticated-orcid":false,"given":"Kazunori","family":"Kawamura","sequence":"first","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"SHI Accelerator Service Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hanyu","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"SHI Accelerator Service Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuki","family":"Nengaki","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"SHI Accelerator Service Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Arashi","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"Tokyo Nuclear Services Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"SHI Accelerator Service Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"Tokyo Nuclear Services Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Togashi","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"Tokyo Nuclear Services Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"Tokyo Nuclear Services Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"},{"name":"Tokyo Nuclear Services Ltd.  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeaki","family":"Saijo","sequence":"additional","affiliation":[{"name":"Sohyaku Innovative Research Division Mitsubishi Tanabe Pharma Corporation  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Sohyaku Innovative Research Division Mitsubishi Tanabe Pharma Corporation  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Obokata","sequence":"additional","affiliation":[{"name":"Sohyaku Innovative Research Division Mitsubishi Tanabe Pharma Corporation  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010021\u201005269\u20104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010021\u201005235\u20100"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969\u20108051(97)00032\u20102"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2996"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200800222"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2021.09.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3540"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0883\u20102889(87)90003\u20107"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400772t"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2016.07.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3890"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.18893\/kakuigaku.tr.1503"},{"key":"e_1_2_7_14_1","unstructured":"International Conference on Harmonization.Guideline for elemental impurities: Q3D. Available at:https:\/\/database.ich.org\/sites\/default\/files\/Q3D-R1EWG_Document_Step4_Guideline_2019_0322.pdf. Accessed December 13 2021."}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.3965","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jlcr.3965","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.3965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:23:49Z","timestamp":1760639029000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.3965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,15]]}},"alternative-id":["10.1002\/jlcr.3965"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.3965","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,9]]},"assertion":[{"value":"2021-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}