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The versatile chemical properties of copper add to the importance of this isotope in medicinal investigation. [<jats:sup>64<\/jats:sup>Cu][Cu (ATSM)] has shown to be a viable candidate for imaging of tumor hypoxia; a critical tumor microenvironment characteristic that typically signifies tumor progression and resistance to chemo\u2010radiotherapy. Various production and radiosynthesis methods of [<jats:sup>64<\/jats:sup>Cu][Cu (ATSM)] exist in labs, but usually involved non\u2010standardized equipment with varying production qualities and may not be easily implemented in wider hospital settings. [<jats:sup>64<\/jats:sup>Cu][Cu (ATSM)] was synthesized on a modified GE TRACERlab FXN automated synthesis module. End\u2010of\u2010synthesis (EOS) molar activity of [<jats:sup>64<\/jats:sup>Cu][Cu (ATSM)] was 2.2\u20135.5\u2009Ci\/\u03bcmol (HPLC), 2.2\u20132.6\u2009Ci\/\u03bcmol (ATSM\u2010titration), and 3.0\u20134.4\u2009Ci\/\u03bcmol (ICP\u2010MS). Radiochemical purity was determined to be &gt;99% based on radio\u2010HPLC. The final product maintained radiochemical purity after 20\u2009h. We demonstrated a simple and feasible process development and quality control protocols for automated cyclotron production and synthesis of [<jats:sup>64<\/jats:sup>Cu][Cu (ATSM)] based on commercially distributed standardized synthesis modules suitable for PET imaging and theranostic studies.<\/jats:p>","DOI":"10.1002\/jlcr.3973","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T02:24:55Z","timestamp":1650853495000},"page":"191-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Development of an automated production process of [<sup>64<\/sup>Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7109-7802","authenticated-orcid":false,"given":"Tengzhi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Physics Norwegian University of Science and Technology  Trondheim Norway"},{"name":"Department of Radiology and Nuclear Medicine St. Olavs Hospital, Trondheim University Hospital  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrine R\u00f8e","family":"Redalen","sequence":"additional","affiliation":[{"name":"Department of Physics Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-8980","authenticated-orcid":false,"given":"Morten","family":"Karlsen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine St. Olavs Hospital, Trondheim University Hospital  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.18112"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.04.027"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2015.00058"},{"issue":"4","key":"e_1_2_7_5_1","first-page":"365","article-title":"PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence","volume":"4","author":"Lopci E","year":"2014","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2344"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2009.0674"},{"key":"e_1_2_7_8_1","first-page":"2011","volume-title":"Health Physics and Radiological Health","author":"Johnson TE"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic702440e"},{"key":"e_1_2_7_10_1","first-page":"189","article-title":"A combination of sensitizers with high LET radiations","volume":"3","author":"Raju MR","year":"1978","journal-title":"Br J Cancer Suppl"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553000903564083"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrv042"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13550\u2010020\u201000621\u20105"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969\u20108051(96)00157\u20106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/instruments2030017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0969\u20108043(93)90172\u20107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969\u20108051(03)00024\u20106"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2007.05.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2009.02.060"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3706"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.114.140392"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2014.02.015"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2005.03.010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"crossref","unstructured":"ShaoX HoareauR HockleyBG et al.Highlighting the versatility of the tracerlab synthesis modules. 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