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An efficient and readily scalable anodic methoxylation of <jats:italic>N<\/jats:italic>\u2010formylpiperidine in an undivided microfluidic electrolysis cell delivers methoxylated piperidine <jats:bold>3<\/jats:bold>, which is a precursor to a <jats:italic>N<\/jats:italic>\u2010formyliminium ion and enables C\u2010nucleophiles to be introduced at the 2\u2010position. The isotopically labelled <jats:italic>N<\/jats:italic>\u2010deuteriomethyl group is installed using the Eschweiler\u2013Clarke reaction with formic acid\u2010<jats:italic>d<\/jats:italic><jats:sub>2<\/jats:sub> and unlabelled formaldehyde. 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