{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:11Z","timestamp":1787162831084,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["2035\u201000077B"],"award-info":[{"award-number":["2035\u201000077B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    CRANAD\u2010102, a selective near\u2010infrared fluorescent tracer targeting soluble amyloid\u2010\u03b2 (A\u03b2) species, has recently attracted attention due to its potential to be used as a diagnostic tool for early stages of Alzheimer's disease (AD). Development of a positron emission tomography (PET) tracer based on CRANAD\u2010102 could as such allow to noninvasively study soluble and protofibrillar species of A\u03b2 in humans. These soluble and protofibrillar species are thought to be responsible to cause AD. Within this work, we successfully\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010labeled CRANAD\u2010102 via a Suzuki\u2013Miyaura reaction in a RC\u0421 of 48\u2009\u00b1\u00a09%, with a RCP of &gt;96% and a molar activity (A\n                    <jats:sub>m<\/jats:sub>\n                    ) of 25\u2009\u00b1\u00a07\u00a0GBq\/\u03bcmol. Future studies have to be conducted to evaluate if [\n                    <jats:sup>11<\/jats:sup>\n                    C]CRANAD\u2010102 can be used to detect soluble protofibrils in vivo and if [\n                    <jats:sup>11<\/jats:sup>\n                    C]CRANAD\u2010102 can be used to detect AD earlier as possible with current diagnostics.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.4060","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:53:46Z","timestamp":1693529626000},"page":"393-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of\n                    <sup>11<\/sup>\n                    C\u2010labeled CRANAD\u2010102 for positron emission tomography imaging of soluble A\u03b2\u2010species"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-1818","authenticated-orcid":false,"given":"Markus","family":"Staudt","sequence":"first","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Shalgunov","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Cluster for Molecular Imaging, Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiken","family":"Nedergaard","sequence":"additional","affiliation":[{"name":"Center for Translational Neuromedicine, Department of Neurosurgery University of Rochester Medical Center  Rochester New York USA"},{"name":"Center for Translational Neuromedicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7788-513X","authenticated-orcid":false,"given":"Matthias M.","family":"Herth","sequence":"additional","affiliation":[{"name":"Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Physiology Nuclear Medicine &amp; PET, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Textbook of Drug Design and Discovery: In Vivo Imaging in Drug Discovery","author":"Kristensen JL","year":"2017"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics9020065"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2971"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/416535a"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3028"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00731G"},{"key":"e_1_2_5_8_1","first-page":"613","volume-title":"Amyloid Toxicity in Alzheimer's Disease. Reviews in the Neurosciences","author":"Reiss AB","year":"2018"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00813-8"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10759"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.213140"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15101191"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb5924"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9047043"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja405239v"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1505420112"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2AN01327D"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7SC02050C"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969\u20108043(96)00177\u20107"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2020.11.003"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.11.001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00095"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.04.044"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.128983"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.4060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:08:05Z","timestamp":1760641685000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.4060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,31]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jlcr.4060"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.4060","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,31]]},"assertion":[{"value":"2023-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}