{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:23:54Z","timestamp":1785932634909,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EB029752"],"award-info":[{"award-number":["EB029752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Nucleophilic copper\u2010mediated radioiodination (CMRI) of organoboronic precursors with radioiodides is a promising method of radioiodination. The previously reported CMRI has demonstrated its great potential and scope of labeling for the radiosynthesis of radioiodine\u2010labeled compounds. However, the reported protocols (using a small amount\/volume of radioactivity) are practically not reproducible in large\u2010scale CMRI, in which the radioactivity was usually provided in a bulk alkaline solution. A large amount of water and a strong base are incompatible with CMRI. To overcome these issues in large\u2010scale CMRI, we have developed a simple protocol for large\u2010scale CMRI. The bulk water was removed under a flow of inert gas at 110\u00b0C, and the strong base (i.e., NaOH) was neutralized with an acid, pyridinium <jats:italic>p<\/jats:italic>\u2010toluenesulfonate or <jats:italic>p<\/jats:italic>\u2010toluenesulfonic acid. In the model reactions of [<jats:sup>123<\/jats:sup>I]KX\u20101, a PARP\u20101 radioligand for Auger radiotherapy, radiochemical conversions were significantly improved after neutralization of the base, and the addition of additional acids was tolerated and favorable for the reactions. Using this protocol, [<jats:sup>123<\/jats:sup>I]KX\u20101 was radiosynthesized from 20\u2009mCi (0.74\u2009GBq) of [<jats:sup>123<\/jats:sup>I]iodide in high radiochemical yields, high radiochemical purity, and high molar activity. This protocol should be applicable to the radiosynthesis of other compounds with radioiodine via CMRI.<\/jats:p>","DOI":"10.1002\/jlcr.4065","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:12:26Z","timestamp":1695341546000},"page":"435-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A practical protocol for large\u2010scale copper\u2010mediated radioiodination of organoboronic precursors: Radiosynthesis of [<sup>123<\/sup>I]KX\u20101 for Auger radiotherapy"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-4878","authenticated-orcid":false,"given":"Dong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Radiology, School of Medicine Washington University in Saint Louis  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Washington University in Saint Louis  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine Washington University in Saint Louis  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC07417K"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b00232"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201604105"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2022.116915"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3925"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201405586"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b02875"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c01974"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00280a029"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043083"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40336\u2010020\u201000368\u2010y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25246029"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201019\u20102440"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.4065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:12:00Z","timestamp":1760638320000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.4065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":13,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/jlcr.4065"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.4065","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"2023-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}