{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:33:15Z","timestamp":1760661195005,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2024,6,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Rimsulfuron is a sulfonylurea herbicide that controls grass and broadleaf weeds in maize, potatoes, fruits, nuts, and other crops. It can also be used as a burndown herbicide to clear invasive weed species along roadsides and other nonagricultural land. Rimsulfuron acts as an acetolactase synthase (ALS) inhibitor, blocking the synthesis of essential amino acids required for plant growth. As is common practice, rimsulfuron has been subject to periodic reviews by regulatory agencies for reregistration since its introduction into the market in the early 1990s. The goal of these reviews is to ensure that the herbicide carries out its intended use without creating adverse side effects to humans and the environment. Since scientific methods are continually evolving and being developed, global regulatory agencies can require additional studies to address data gaps for pesticide renewals. During this reregistration process for rimsulfuron, a new confined rotational crop study was required to address a data gap requested by the European Food Safety Authority (EFSA). Consequently, the corresponding pyridine and pyrimidine radiolabeled [<jats:sup>14<\/jats:sup>C]rimsulfuron and [M\u2009+\u20093] stable isotopes of rimsulfuron were synthesized for this study to support the reregistration process.<\/jats:p>","DOI":"10.1002\/jlcr.4096","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T01:18:48Z","timestamp":1715044728000},"page":"263-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Radiolabeled [<sup>14<\/sup>C]Rimsulfuron and Stable Isotope Labeled Rimsulfuron\u2010[M\u2009+\u20093] to Support Crop Metabolism Studies for Reregistration"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9645-5167","authenticated-orcid":false,"given":"Lindsey\u00a0G.","family":"Horty","sequence":"first","affiliation":[{"name":"Corteva Agriscience  Indianapolis Indiana USA"},{"name":"Department of Discovery Process Sciences, Regulatory Chemistry Group Corteva Agriscience  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Martin","sequence":"additional","affiliation":[{"name":"Corteva Agriscience  Indianapolis Indiana USA"},{"name":"Department of Discovery Process Sciences, Regulatory Chemistry Group Corteva Agriscience  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"P. H. T.Liang \u201cHerbicidal and Plant Growth\u2010Regulating Pyridinesulfonylureas Their Compositions and the Method of Weed Control Using Them \u201d WO8804297 June 16 (1988)."},{"issue":"9","key":"e_1_2_7_3_1","first-page":"7447","article-title":"Peer Review of the Pesticide Risk Assessment of the Active Substance Rimsulfuron","volume":"20","author":"Alvarez F.","year":"2022","journal-title":"EFSA Journal"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106879"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b02807"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580310808"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.1887"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01129a518"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.2580270615"},{"key":"e_1_2_7_10_1","unstructured":"Y.Liu L.Sun F.Mao Y.Shen andH.Zhang \u201cPreparation of 2\u2010Halo\u20103\u2010Substituted Hydrocarbyl Sulfonyl Pyridine and Its Intermediate by Microwave as Agrochemical Fungicides \u201d CN106518757 January 25 (2017)."},{"issue":"3","key":"e_1_2_7_11_1","first-page":"26","article-title":"Synthesis of Sulfonylurea Herbicide Rimsulfuron","volume":"35","author":"Tan X.","year":"2005","journal-title":"Jingxi Huagong Zhongjianti"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.4096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:56:36Z","timestamp":1760637396000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.4096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,6]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,6,15]]}},"alternative-id":["10.1002\/jlcr.4096"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.4096","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"type":"print","value":"0362-4803"},{"type":"electronic","value":"1099-1344"}],"subject":[],"published":{"date-parts":[[2024,5,6]]},"assertion":[{"value":"2024-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}