{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:16:41Z","timestamp":1778941001587,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"9-10","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Radiolabeled alcohols have been investigated for their use in the measurement of cerebral blood flow for years. In particular, [<jats:sup>11<\/jats:sup>C]butanol has been employed as a freely diffusible tracer with appreciable tissue retention and good solubility in both lipid and aqueous compartments. It is an appropriate radiotracer for the assessment of blood supply and for the comparative evaluation of substrate utilization with blood flow. Herein, we describe a no\u2010carrier\u2010added [<jats:sup>11<\/jats:sup>C]butanol radiosynthesis using the GE FASTLab 2 to leverage the benefits of a cassette\u2010based workflow, and we compare it to our legacy radiosynthesis using GE TracerLab FX modules. Using the FASTLab 2, [<jats:sup>11<\/jats:sup>C]butanol was synthesized in 21\u2009min with a radiochemical yield of 4%\u20138% (<jats:italic>n<\/jats:italic>\u2009=\u20093) and a radiochemical purity of &gt;\u200990%. Synthesis on the FASTLab was fast, reliable, and comparable to syntheses using TracerLab FX modules.<\/jats:p>","DOI":"10.1002\/jlcr.4158","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T03:24:20Z","timestamp":1754018660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fully Automated Radiosynthesis of No\u2010Carrier\u2010Added [<sup>11<\/sup>C]Butanol Using the GE FASTLab 2 Module"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-9522","authenticated-orcid":false,"given":"Ivan\u00a0E.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmacy University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7271-6567","authenticated-orcid":false,"given":"Jason\u00a0A.","family":"Witek","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan\u00a0J.","family":"Pakula","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradford\u00a0D.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-0136","authenticated-orcid":false,"given":"Marianna","family":"Dakanali","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6505-0450","authenticated-orcid":false,"given":"Peter\u00a0J.\u00a0H.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, College of Pharmacy University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Radiology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Pharmacology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1976.230.2.543"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1991.127"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.94"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1132077"},{"issue":"11","key":"e_1_2_8_7_1","first-page":"540","article-title":"11C\u2010Butanol for Imaging of the Blood\u2010Flow Distribution in Tumor\u2010Bearing Animals","volume":"10","author":"Knapp W. 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