{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:46:11Z","timestamp":1787237171101,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22401151"],"award-info":[{"award-number":["22401151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220408"],"award-info":[{"award-number":["BK20220408"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Carbon\u201011 (\n                    <jats:sup>11<\/jats:sup>\n                    C)\u2010labeled radiotracers are invaluable tools in positron emission tomography (PET), enabling real\u2010time visualization of biochemical processes with high sensitivity and specificity. Among the various\n                    <jats:sup>11<\/jats:sup>\n                    C synthons, cyclotron\u2010produced [\n                    <jats:sup>11<\/jats:sup>\n                    C]CO\n                    <jats:sub>2<\/jats:sub>\n                    is a fundamental precursor, though its direct incorporation into complex molecules has traditionally been limited by its low reactivity, gaseous form, and short half\u2010life. Recent advances in [\n                    <jats:sup>11<\/jats:sup>\n                    C]CO\n                    <jats:sub>2<\/jats:sub>\n                    fixation chemistry through both nonphotocatalytic and photocatalytic methods have significantly expanded its utility in the synthesis of structurally diverse compounds, including carboxylic acids, carbonates, carbamates, amides, and ureas. This review summarizes key developments in [\n                    <jats:sup>11<\/jats:sup>\n                    C]CO\n                    <jats:sub>2<\/jats:sub>\n                    radiolabeling strategies, with critical evaluation of substrate scope, radiochemical yield, molar activity, and clinical translation potential. These advances collectively expand the synthetic versatility of [\n                    <jats:sup>11<\/jats:sup>\n                    C]CO\n                    <jats:sub>2<\/jats:sub>\n                    and pave the way for the development of structurally diverse and clinically translatable PET imaging agents.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.4162","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T13:22:37Z","timestamp":1757337757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recent Advances in\n                    <sup>11<\/sup>\n                    C\u2010Labeling With [\n                    <sup>11<\/sup>\n                    C]CO\n                    <sub>2<\/sub>\n                    for PET Imaging"],"prefix":"10.1002","volume":"68","author":[{"given":"Tianshuai","family":"Zhu","sequence":"first","affiliation":[{"name":"National Key Laboratory for the Development and Utilization of Forest Food Resources, Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for the Development and Utilization of Forest Food Resources, Jiangsu Co\u2010Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital With Nanjing Medical University  Nanjing Jiangsu 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0782426"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2290"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00200"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201900321"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805501"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36377-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2020.02.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201806285"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3528"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00573"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01571"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109342"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002341"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC00449A"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00524"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15556-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3907"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-01074-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7641304"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c02419"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA03966D"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3568"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01778"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00729"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05031H"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41181-020-00103-y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC02665H"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcou.2022.102137"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.4075"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c12819"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00398"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c04679"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000389"}],"container-title":["Journal 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