{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:55:57Z","timestamp":1773770157718,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG077700"],"award-info":[{"award-number":["R01 AG077700"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to further understand the tau imaging agent, flortaucipir (T807), by making small modifications and assess its effect on tau protein binding in Alzheimer's disease (\n                    <jats:sc>AD<\/jats:sc>\n                    ). Thus, the fluoropyridyl group in T807 was replaced with an iodine atom. We report here the development and preliminary evaluation of [\n                    <jats:sup>125<\/jats:sup>\n                    I]7\u2010iodo\u20105H\u2010pyrido[4,3\u2010B]indole ([\n                    <jats:sup>125<\/jats:sup>\n                    I]CTAU) in postmortem\n                    <jats:sc>AD<\/jats:sc>\n                    brain slices. Using molecular docking, binding energies of CTAU indicated weaker tau binding compared with T807. In\u00a0vitro tau binding assays in\n                    <jats:sc>AD<\/jats:sc>\n                    brain slices measured IC\n                    <jats:sub>50<\/jats:sub>\n                    of CTAU and T807 as 44\u2009\u00d7\u200910\n                    <jats:sup>\u22129<\/jats:sup>\n                    \u2009M and 3.8\u2009\u00d7\u200910\n                    <jats:sup>\u22129<\/jats:sup>\n                    \u2009M, respectively. [\n                    <jats:sup>125<\/jats:sup>\n                    I]CTAU was synthesized in high radiochemical purity and molar activity (90\u2009TBq\/mmole). Binding of [\n                    <jats:sup>125<\/jats:sup>\n                    I]CTAU in the\n                    <jats:sc>AD<\/jats:sc>\n                    grey matter (GM) was observed, with lower nonspecific binding in the white matter (GM\/WM\u2009=\u20092.3). Tau binding drugs (T807 and MK\u20106240, 10\u2009\u03bcM) were both able to displace ~90% of bound [\n                    <jats:sup>125<\/jats:sup>\n                    I]CTAU in\n                    <jats:sc>AD<\/jats:sc>\n                    brain slices. Clorgyline (10\u2009\u03bcM), a monoamine oxidase A inhibitor, decreased the binding of [\n                    <jats:sup>125<\/jats:sup>\n                    I]CTAU to 72% of total. In\n                    <jats:sc>AD<\/jats:sc>\n                    brain slices, [\n                    <jats:sup>125<\/jats:sup>\n                    I]CTAU exhibited a similar binding profile with the tau imaging agent [\n                    <jats:sup>125<\/jats:sup>\n                    I]IPPI. Although [\n                    <jats:sup>125<\/jats:sup>\n                    I]CTAU appears promising in\u00a0vitro, any off\u2010target issues need to be further studied to determine its use in\n                    <jats:sc>AD<\/jats:sc>\n                    \u2010related dementias (ADRD).\n                  <\/jats:p>","DOI":"10.1002\/jlcr.70003","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T08:14:56Z","timestamp":1768032896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis and Evaluation of Radioiodinated [\n                    <sup>125<\/sup>\n                    I]7\u2010Iodo\u20105H\u2010Pyrido[4,3\u2010B]Indole ([\n                    <sup>125<\/sup>\n                    I]CTAU) in Postmortem Human Alzheimer's Disease Brain"],"prefix":"10.1002","volume":"69","author":[{"given":"Chloe\u00a0C.","family":"McNamara","sequence":"first","affiliation":[{"name":"Preclinical Imaging, Department of Radiological Sciences University of California\u2010Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes\u00a0P.","family":"Biju","sequence":"additional","affiliation":[{"name":"Preclinical Imaging, Department of Radiological Sciences University of California\u2010Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma\u00a0Lynn\u00a0M.","family":"Hipolito","sequence":"additional","affiliation":[{"name":"Preclinical Imaging, Department of Radiological Sciences University of California\u2010Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngan\u00a0T.\u00a0B.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Preclinical Imaging, Department of Radiological Sciences University of California\u2010Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Liang","sequence":"additional","affiliation":[{"name":"Preclinical Imaging, Department of Radiological Sciences University of California\u2010Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1009-877X","authenticated-orcid":false,"given":"Jogeshwar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Preclinical Imaging, Department of Radiological Sciences University of California\u2010Irvine  Irvine California 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