{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:11:19Z","timestamp":1773033079274,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Florasulam is a triazolopyrimidine herbicide that controls broadleaf and grass weeds in cereal crops and turf. It acts as an acetolactase synthase (ALS) inhibitor, blocking the synthesis of essential amino acids required for plant growth. Due to its potency, florasulam is effective at very low application rates making it cost\u2010effective with reduced environmental off\u2010target effects. As is common practice, florasulam has been subject to periodic reviews by regulatory agencies during re\u2010registration requirements since its introduction into the market in 1998. The goal of these reviews is to ensure that the herbicide carries out its intended use without creating adverse side effects to humans and the environment. Since scientific methods are continually evolving and being developed, global regulatory agencies can require additional studies to address data gaps for pesticide renewals. During this re\u2010registration process for florasulam, new environmental fate studies were conducted to meet new European Food Safety Authority (EFSA) guidelines. Consequently, florasulam\u2010[triazole(\n 13<\/jats:sup>\n C,\n 15<\/jats:sup>\n N\n 2<\/jats:sub>\n )] and florasulam\u2010[phenyl(\n 13<\/jats:sup>\n C\n 6<\/jats:sub>\n )] stable isotopes were synthesized to support the re\u2010registration process.\n <\/jats:p>","DOI":"10.1002\/jlcr.70005","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T06:24:47Z","timestamp":1769408687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Florasulam Stable Isotopes to Enable Identification of Degradants by Mass Spectrometry for Re\u2010registration Studies"],"prefix":"10.1002","volume":"69","author":[{"given":"Caroline","family":"Long","sequence":"first","affiliation":[{"name":"Corteva Agriscience Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9645-5167","authenticated-orcid":false,"given":"Lindsey\u00a0G.","family":"Horty","sequence":"additional","affiliation":[{"name":"Corteva Agriscience Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106879"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b02807"},{"key":"e_1_2_8_4_1","unstructured":"T. A.Olmsteadet. al \u201cPreparation of 5\u2010Alkoxy\u20101 2 4\u2010Triazolo[1.5\u2010c]pyrimidine\u20102(3H)\u2010Thiones as Intermediates for 2\u2010Chlorosulfonyl\u20105\u2010Alkoxy\u20101 2 4\u2010Triazolo[1 5\u2010c]pyrimidines \u201d WO 9512596 A1 1995."},{"key":"e_1_2_8_5_1","unstructured":"D. L.Pearson T. J.Adaway andJ. J.Tai \u201cPreparation of Heterocyclic Sulfonyl Chlorides by Phase Transfer Chlorination of the Corresponding Disulfides \u201d WO 9900392 A11999."},{"key":"e_1_2_8_6_1","unstructured":"D. L.PearsonandT. 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