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The key to ensuring that the tumor receives an adequate radiation dose while minimizing the dose to normal tissues is to optimize the trade\u2010off between tumor control and the probability of normal tissue complications. To accurately determine a patient's internal radiation dose, pre\u2010treatment dose planning and post\u2010treatment dose verification using dosimetric methods are recommended and increasingly considered best practice in Y\u2010SIRT, where feasible. Due to the increased demand for personalized treatment and dose accuracy in clinical practice, Y\u2010SIRT dosimetry has transitioned from organ\u2010level to voxel\u2010level dosimetry. This paper introduces the relevant principles and development history of Y\u2010SIRT dosimetry for resin microspheres. It also discusses the clinical performance, influencing factors and practical applications of relevant dosimetry methods. These include body surface area (BSA) method, MIRD multi\u2010compartment model method, and partition model method; voxel\u2010S\u2010value (VSV); local deposition method (LDM); and Monte Carlo (MC) method. Finally, it covers the subsequent development of resin microsphere Y\u2010SIRT dosimetry.<\/jats:p>","DOI":"10.1002\/jlcr.70022","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:19:09Z","timestamp":1773029949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dosimetric Development of Yttrium\u201090 Resin Microspheres for Selective Internal Radiation Therapy: Current Status and Perspectives"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6415-177X","authenticated-orcid":false,"given":"Zhong\u2010Bin","family":"Hang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy Beijing Normal University  Beijing China"},{"name":"Key Laboratory of Multiscale Spin Physics (Ministry of Education) Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Wei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Yu","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy Beijing Normal University  Beijing China"},{"name":"Key Laboratory of Multiscale Spin Physics (Ministry of Education) Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian\u2010Tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke\u2010Xin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Technology and Application China Institute of Atomic Energy  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Zhe","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Technology and Application China Institute of Atomic Energy  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy Beijing Normal University  Beijing China"},{"name":"Key Laboratory of Multiscale Spin Physics (Ministry of Education) Beijing Normal University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuo\u2010Xiang","family":"He","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital Tsinghua University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"17","article-title":"Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2024 Edition)","volume":"10","author":"China o. t. 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