{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:33:13Z","timestamp":1789601593698,"version":"build-2803163510"},"reference-count":269,"publisher":"Wiley","issue":"4-6","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancer remains one of the most challenging medical conditions. Nanotechnology is revolutionizing the approach to cancer management as an efficient tool for early diagnosis, therapy and monitoring. Nanoparticles (NPs) have shown promising results in advancing precision medicine by integrating diagnostic imaging and targeted therapy within a single platform, a concept of theranostics. Nanocarriers are synthesized via the use of biocompatible materials that are functionalized with specific ligands that bind to receptors that are overexpressed on the surface of cancer cells. For theranostic purposes, these NPs are loaded with suitable radioisotopes that emit gamma, positron, alpha or beta radiation for imaging and\/or therapy. Despite the significant successes, most of the work is still at the preclinical stages awaiting clinical translation. In this review, a comprehensive examination of the current state of receptor\u2010targeted radiotheranostic NPs is presented, with a focus on their design, functionalization, receptor\u2010specific targeting, and clinical translational potential. The role of key tumor markers is highlighted in guiding NP delivery and improving precision and therapy. The exploration of these cutting\u2010edge advancements and associated challenges will provide insights into the revolution of radiotheranostic nanomedicine and its impact on the future of precision oncology.<\/jats:p>","DOI":"10.1002\/jlcr.70028","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:40:31Z","timestamp":1775536831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radiotheranostics With Nanoparticles: Precision Targeting in Receptor\u2010Overexpressing Tumors"],"prefix":"10.1002","volume":"69","author":[{"given":"Evalyne\u00a0J.","family":"Cheruiyot","sequence":"first","affiliation":[{"name":"Institute of Nuclear Science &amp; Technology University of Nairobi  Nairobi Kenya"},{"name":"Integrated Molecular Imaging Center Kenyatta University, Teaching, Referral &amp; Research Hospital  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0M.","family":"Wanjeh","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Science &amp; Technology University of Nairobi  Nairobi Kenya"},{"name":"Integrated Molecular Imaging Center Kenyatta University, Teaching, Referral &amp; Research Hospital  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u00a0K.","family":"Birir","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Science &amp; Technology University of Nairobi  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan\u00a0W.","family":"Karuga","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Science &amp; Technology University of Nairobi  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-0937","authenticated-orcid":false,"given":"Beatrice\u00a0K.","family":"Amugune","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Nairobi  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia\u00a0G.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Missouri  Columbia Missouri USA"},{"name":"Molecular Imaging and Theranostics Center University of Missouri  Columbia Missouri USA"},{"name":"Research Service Harry S. 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