{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:48:21Z","timestamp":1792176501853,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"10-11","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24zf0127012"],"award-info":[{"award-number":["24zf0127012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We clinically investigated (\n                    <jats:italic>S<\/jats:italic>\n                    )\u20105\u2010methoxymethyl\u20103\u2010[6\u2010(4,4,4\u2010trifluorobutoxy)benzo[\n                    <jats:italic>d<\/jats:italic>\n                    ]isoxazol\u20103\u2010yl]oxazolidin\u20102\u2010[\n                    <jats:sup>11<\/jats:sup>\n                    C]\u2010one ([\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1188) as a positron emission tomography tracer for imaging monoamine oxidase B. To perform clinical imaging studies at our institute, we established a routine method for preparing the [\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1188 injection using a one\u2010pot [\n                    <jats:sup>11<\/jats:sup>\n                    C]CO\n                    <jats:sub>2<\/jats:sub>\n                    fixation method. We successfully prepared the [\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1188 injection using a\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010labeling synthesizer and sterile isolator. The radiosynthesis time and decay\u2010corrected radiochemical yield based on [\n                    <jats:sup>11<\/jats:sup>\n                    C]CO\n                    <jats:sub>2<\/jats:sub>\n                    were below 30\u2009min and 49%\u2009\u00b1\u200910% postirradiation (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009104), respectively. At the end of synthesis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009104), the molar activity was 180\u2009\u00b1\u200957\u2009GBq\/\u03bcmol, and the radiochemical purity exceeded 99%. The results of [\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1188 injection complied fully with our in\u2010house quality control and quality assurance criteria, confirming a reliable supply of high\u2010quality [\n                    <jats:sup>11<\/jats:sup>\n                    C]SL25.1188 formulation with adequate radioactivity for use in clinical imaging studies.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.70035","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T02:15:30Z","timestamp":1787364930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reliable One\u2010Pot Automated Preparation of [\n                    <sup>11<\/sup>\n                    C]SL25.1188 for Use in Clinical Imaging Studies"],"prefix":"10.1002","volume":"69","author":[{"given":"Hiroki","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ohkubo","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"SHI Accelerator Service Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaito","family":"Tsukagoe","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"SHI Accelerator Service Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"Tokyo Nuclear Services Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Arashi","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"Tokyo Nuclear Services Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuto","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"Tokyo Nuclear Services Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeru","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"Tokyo Nuclear Services Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"SHI Accelerator Service Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"SHI Accelerator Service Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Muto","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"Tokyo Nuclear Services Co. Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuki","family":"Nengaki","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"},{"name":"SHI Accelerator Service Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakana","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Fujinaga","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-678X","authenticated-orcid":false,"given":"Kazunori","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3001-9605","authenticated-orcid":false,"given":"Ming\u2010Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science National Institutes for Quantum Science and Technology (QST)  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.1492"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20703"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.34"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.0044"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2021.10.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010025\u201007542\u20102"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802610793176710"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2009.08.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.1908"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc42236d"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3528"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3965"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.3890"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.18893\/kakuigaku.tr.1503"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.70035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jlcr.70035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.70035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:06:59Z","timestamp":1792174019000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.70035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":14,"journal-issue":{"issue":"10-11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jlcr.70035"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.70035","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70035"}}