{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:48:22Z","timestamp":1792176502396,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"10-11","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB031785"],"award-info":[{"award-number":["R01EB031785"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007259","name":"Stony Brook University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Monoamine oxidase B (MAO\u2010B) is highly expressed in reactive astrocytes and is implicated in multiple neurodegenerative and neuropsychiatric conditions, making it an important PET imaging target. Building on the promising PET imaging properties of (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(2\u2010methylpyrid\u20105\u2010yl)\u20106\u2010[(3\u2010\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010fluoro\u20102\u2010hydroxy)propoxy]quinoline ((\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]SMBT\u20101), we developed a carbon\u201011\u2010labeled analog, (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010(2\u2010\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010methylpyrid\u20105\u2010yl)\u20106\u2010[(3\u2010fluoro\u20102\u2010hydroxy)propoxy]quinoline ((\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010[\n                    <jats:sup>11<\/jats:sup>\n                    C]SMBT\u20101). The short half\u2010life of carbon\u201011 (t\n                    <jats:sub>1\/2<\/jats:sub>\n                    \u2009=\u200920.7\u2009min) enables same\u2010day, repeat scans and pharmacological challenge studies within the same subject. An efficient radiosynthesis of (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010[\n                    <jats:sup>11<\/jats:sup>\n                    C]SMBT\u20101 was developed via palladium\u2010mediated Stille cross\u2010coupling followed by acid deprotection. The radiosynthesis was completed within 28.4\u2009\u00b1\u20090.9\u2009min from end of bombardment (EOB) (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093), providing (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010[\n                    <jats:sup>11<\/jats:sup>\n                    C]SMBT\u20101 in 11.9%\u2009\u00b1\u20092.7% radiochemical yield (decay\u2010corrected) with final product activity of 1.76\u2009\u00b1\u20090.28\u2009GBq (47.4\u2009\u00b1\u20097.5\u2009mCi) and molar activity of 58.8\u2009\u00b1\u20098.0\u2009GBq\/\u03bcmol (1.59\u2009\u00b1\u20090.22\u2009Ci\/\u03bcmol) at end of synthesis (EOS), high radiochemical purity (&gt;\u200999%) and enantiomeric excess (&gt;\u200999%). The developed radiosynthetic method provides reliable access to (\n                    <jats:italic>S<\/jats:italic>\n                    )\u2010[\n                    <jats:sup>11<\/jats:sup>\n                    C]SMBT\u20101, and in\u00a0vivo evaluation studies are currently underway to further assess its potential for future clinical MAO\u2010B PET imaging applications.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.70037","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:15:43Z","timestamp":1788909343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Practical Radiosynthesis of (\n                    <i>S<\/i>\n                    )\u2010[\n                    <sup>11<\/sup>\n                    C]SMBT\u20101 for MAO\u2010B PET Imaging"],"prefix":"10.1002","volume":"69","author":[{"given":"Hari K.","family":"Akula","sequence":"first","affiliation":[{"name":"PET Research Core, Renaissance School of Medicine Stony Brook University Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumyaranjan","family":"Pati","sequence":"additional","affiliation":[{"name":"PET Research Core, Renaissance School of Medicine Stony Brook University Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Qu","sequence":"additional","affiliation":[{"name":"PET Research Core, Renaissance School of Medicine Stony Brook University Stony Brook New York USA"},{"name":"Department of Psychiatry and Behavioral Health Renaissance School of Medicine at Stony Brook University Stony Brook New York USA"},{"name":"Department of Chemistry Renaissance School of Medicine at Stony Brook University Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Slifstein","sequence":"additional","affiliation":[{"name":"PET Research Core, Renaissance School of Medicine Stony Brook University Stony Brook New York USA"},{"name":"Department of Psychiatry and Behavioral Health Renaissance School of Medicine at Stony Brook University Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Parsey","sequence":"additional","affiliation":[{"name":"PET Research Core, Renaissance School of Medicine Stony Brook University Stony Brook New York USA"},{"name":"Department of Psychiatry and Behavioral Health Renaissance School of Medicine at Stony Brook University Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-8814","authenticated-orcid":false,"given":"Ryuichi","family":"Harada","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Faculty of Medicine Tohoku Medical and Pharmaceutical University Sendai Japan"},{"name":"Research Center for Accelerator and Radioisotope Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-3079","authenticated-orcid":false,"given":"Shozo","family":"Furumoto","sequence":"additional","affiliation":[{"name":"Research Center for Accelerator and Radioisotope Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-7812","authenticated-orcid":false,"given":"Nobuyuki","family":"Okamura","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, Faculty of Medicine Tohoku Medical and Pharmaceutical University Sendai Japan"},{"name":"Research Center for Accelerator and Radioisotope Science Tohoku University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Health Renaissance School of Medicine at Stony Brook University Stony Brook New 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