{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:11:44Z","timestamp":1790158304308,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10-11","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Labelled Comp Radiopharmac"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    1\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]Fluoroethyl\u2010indole propionic acid (1\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]\u2010IPA), a fluorinated analogue of indole\u20103\u2010propionic acid (IPA), shows considerable promise as a PET tracer for imaging BxPC\u20103 pancreatic cancer xenografts. In the present study, we report a straightforward automated synthesis protocol that employs cartridge\u2010based purification, providing 1\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]\u2010IPA in a form suitable for human use. This method was developed in compliance with good manufacturing practice (GMP) guidelines, and the final product meets the established release specifications for radiopharmaceuticals. The automated synthesis was carried out via a two\u2010step, one\u2010pot procedure, which involved [\n                    <jats:sup>18<\/jats:sup>\n                    F]fluorination of methyl 1\u2010(2\u2010tosyloxyethyl)\u20101H\u2010indole\u20103\u2010propionate, subsequent hydrolysis with sodium hydroxide, and purification using a series of commercially available solid\u2010phase extraction cartridges, thereby eliminating the need for preparative high\u2010performance liquid chromatography (preparative HPLC). Using this one\u2010pot approach on a modified commercial GE TRACERlab FX\u2010FN radiosynthesis module, the final product was obtained with high uncorrected radiochemical yields (&gt;\u200935 %) and radiochemical purity (&gt;\u200995 %). Collectively, these results establish the GE TRACERlab FX\u2010FN radiosynthesis module as a robust, flexible, and cost\u2010effective platform for the routine clinical production of 1\u2010[\n                    <jats:sup>18<\/jats:sup>\n                    F]\u2010IPA.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.70040","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:01:47Z","timestamp":1790035307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simple and Efficient Automated Radiosynthesis of 1\u2010[\n                    <sup>18<\/sup>\n                    F]\u2010IPA Using Solid\u2010Phase Extraction Cartridges Purification"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7303-4143","authenticated-orcid":false,"given":"Weixuan","family":"Dong","sequence":"first","affiliation":[{"name":"PET\/CT the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Shen","sequence":"additional","affiliation":[{"name":"PET\/CT the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxi","family":"Chang","sequence":"additional","affiliation":[{"name":"PET\/CT the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhewei","family":"Zhang","sequence":"additional","affiliation":[{"name":"PET\/CT the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Niu","sequence":"additional","affiliation":[{"name":"PET\/CT the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Duan","sequence":"additional","affiliation":[{"name":"PET\/CT the First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01522-4"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.006"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-023-02902-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.02.022"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.011"},{"issue":"0","key":"e_1_2_12_8_1","article-title":"Microbial Metabolite\u2010Driven Immune Reprogramming in Tumor Immunotherapy: Mechanisms and Therapeutic Perspectives","volume":"16","author":"Yao L.","year":"2025","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29194770"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3MD00677H"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092411"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2025.106877"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-024-01750-y"},{"key":"e_1_2_12_14_1","first-page":"1","article-title":"Indole\u20103\u2010Propionic Acid Drives Dendritic H3K27 Acetylation to Enhance CD8+ T Cell Immunity in Hepatocellular Carcinoma","volume":"16","author":"Zhao R.","year":"2026","journal-title":"Cancer Science"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.4027"},{"issue":"6","key":"e_1_2_12_16_1","first-page":"1020","article-title":"Production of 2\u201018F\u2010Fluorobutyric Acid and as a PET Imaging Agent for Prostate Cancer","volume":"45","author":"Dong W. X.","year":"2024","journal-title":"Journal of Xi'an Jiaotong University"}],"container-title":["Journal of Labelled Compounds and Radiopharmaceuticals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.70040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jlcr.70040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jlcr.70040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:39:48Z","timestamp":1790156388000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jlcr.70040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":15,"journal-issue":{"issue":"10-11","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jlcr.70040"],"URL":"https:\/\/doi.org\/10.1002\/jlcr.70040","archive":["Portico"],"relation":{},"ISSN":["0362-4803","1099-1344"],"issn-type":[{"value":"0362-4803","type":"print"},{"value":"1099-1344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70040"}}