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We prepared 17.8\u2009g with an overall synthetic yield of 42%. The labeled atoms are strategically placed to resist removal by known metabolic reactions. The NMR spectral features of the\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010labeled nicotinamide are presented and discussed in detail. We also demonstrate that three heavy atoms are sufficient to achieve &gt;\u20091000:1 mass spectral signal resolution in mixtures with naturally occurring, unlabeled nicotinamide. This material is intended for pharmacokinetic studies in human volunteers.\n                  <\/jats:p>","DOI":"10.1002\/jlcr.70041","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:32:43Z","timestamp":1791531163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of USP Grade [2,3,7\u2010\n                    <sup>13<\/sup>\n                    C\n                    <sub>3<\/sub>\n                    ]\u2010Nicotinamide for Human Pharmacokinetic Studies"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5746-7261","authenticated-orcid":false,"given":"Bruce G.","family":"Szczepankiewicz","sequence":"first","affiliation":[{"name":"Metro International Biotech LLC  Worcester Massachusetts 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