{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:16:29Z","timestamp":1769721389661,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T00:00:00Z","timestamp":1563321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17ek0109276"],"award-info":[{"award-number":["JP17ek0109276"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K21179"],"award-info":[{"award-number":["16K21179"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Very long\u2010chain acyl\u2010CoA dehydrogenase (VLCAD) deficiency is an autosomal recessive mitochondrial fatty acid oxidation disorder that manifests in three clinical forms: (a) severe, (b) milder, and (c) myopathic. Patients with the myopathic form present intermittent muscular symptoms such as myalgia, muscle weakness, and rhabdomyolysis during adolescence or adulthood. Here, the clinical symptoms and serum creatine kinase (CK) levels of a pregnant 31\u2010year\u2010old woman with the myopathic form of VLCAD deficiency were reduced during pregnancy. Clinical symptoms rarely appeared during pregnancy, although she had sometimes suffered from muscular symptoms before pregnancy. When ritodrine was administered for threatened premature labor at 35\u2009weeks of gestation, her CK level was elevated to over 3900\u2009IU\/L. She delivered a full\u2010term baby via cesarean section but suffered from muscle weakness with elevated CK levels soon after delivery. It has been reported that an unaffected placenta and fetus can improve maternal \u03b2\u2010oxidation during pregnancy. However, in our case, the baby was also affected by VLCAD deficiency. These suggest that the clinical symptoms of a woman with VLCAD deficiency might be reduced during pregnancy even if the fetus is affected with VLCAD deficiency.<\/jats:p>","DOI":"10.1002\/jmd2.12061","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T14:00:01Z","timestamp":1563372001000},"page":"17-20","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical course in a patient with myopathic VLCAD deficiency during pregnancy with an affected baby"],"prefix":"10.1002","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0738-7960","authenticated-orcid":false,"given":"Kenji","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ehime University School of Medicine  Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ehime University School of Medicine  Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asami","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yawatahama City General Hospital  Yawatahama Ehime Japan"},{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yawatahama City General Hospital  Yawatahama Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Ochi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yawatahama City General Hospital  Yawatahama Ehime Japan"},{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kozue","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ehime University Graduate School of Medicine  Toon Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Mushimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medical Sciences Kyushu University  Higashi\u2010ku Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Izumo Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Taketani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shimane University Faculty of Medicine  Izumo Shimane 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