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We present a case of severe left ventricular dysfunction with hyperammonemic crisis caused by OTC deficiency which was managed with veno\u2010arterial extracorporeal membrane oxygenation support combined with continuous renal replacement therapy. Aggressive treatment led to normalization of ammonia and full left ventricular recovery.<\/jats:p>","DOI":"10.1002\/jmd2.12135","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T08:43:46Z","timestamp":1591173826000},"page":"12-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful management of a neonate with <scp>OTC<\/scp> deficiency presenting with hyperammonemia and severe cardiac dysfunction with extracorporeal membrane oxygenation support and continuous renal replacement therapy"],"prefix":"10.1002","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7309-1167","authenticated-orcid":false,"given":"Adrian C.","family":"Mattke","sequence":"first","affiliation":[{"name":"Paediatric Intensive Care Unit, Queensland Children's Hospital  South Brisbane Queensland Australia"},{"name":"Queensland Pediatric Cardiac Service, Queensland Children's Hospital  South 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