{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:09:52Z","timestamp":1773266992729,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T00:00:00Z","timestamp":1616284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mucopolysaccharidoses (MPS) is a group of hereditary multisystemic lysosomal disorders. Most neuroimaging studies in MPS have focused on the supratentorial compartment and craniocervical junction abnormalities, and data regarding posterior fossa findings are scarce in the literature. Thus, our purpose is to describe posterior fossa findings on magnetic resonance imaging (MRI) of MPS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed routine MRI scans of MPS patients being followed up at our institution (types I, II, III, IV, and VI), focusing on posterior fossa structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven MPS patients were included. MRI\u2010visible perivascular spaces were commonly found in the midbrain and adjacent to the dentate nuclei (85% and 55% of patients, respectively). White\u2010matter lesion was not identified in most cases. Its most frequent localizations were in the pons and cerebellum (34% and 30% of patients, respectively). Enlargement of cerebrospinal fluid (CSF) spaces in the posterior fossa was present in 55% of individuals and was more frequent in neuronopathic patients (73% vs 40%; <jats:italic>P<\/jats:italic> = .02). Cerebellar volume was classified as normal, apparent macrocerebellum, atrophic, and hypoplastic in 38%, 38%, 21%, and 3% of patients, respectively. A depression of the posterior fossa floor in the midline sagittal plane was found in 22 patients (47%), which was statistical significantly associated with enlargement of CSF spaces (<jats:italic>P<\/jats:italic> = .02) and with apparent macrocerebellum (<jats:italic>P<\/jats:italic> = .03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study compiled the main posterior fossa findings in MPS patients. Classically described in the supratentorial compartment, MRI\u2010visible perivascular spaces, white matter lesions, and enlarged perivascular spaces were also found in the posterior fossa. However, atrophy, which commonly affects cerebral hemispheres, was not the most frequent cerebellar morphology found in our study. Moreover, potential findings for future research were described.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmd2.12212","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T23:24:02Z","timestamp":1616369042000},"page":"32-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Magnetic resonance imaging findings of the posterior fossa in 47 patients with mucopolysaccharidoses: A cross\u2010sectional analysis"],"prefix":"10.1002","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2173-5877","authenticated-orcid":false,"given":"Roberta","family":"Reichert","sequence":"first","affiliation":[{"name":"Graduate Program in Medicine: Surgical Sciences Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliano A.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amauri","family":"Dalla\u2010Corte","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Rio dos Sinos  S\u00e3o Leopoldo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Pinto e Vairo","sequence":"additional","affiliation":[{"name":"Center for Individualized Medicine and Department of Clinical Genomics Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina F. M.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Giugliani","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo R.","family":"Isolan","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicine: Surgical Sciences UFRGS  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Antonio","family":"Stefani","sequence":"additional","affiliation":[{"name":"Graduate Program in Medicine: Surgical Sciences UFRGS  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker394"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399408000550"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.01.052"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000269782.80107.fe"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016150168"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2832"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/59197814"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0510"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/8904_2013_223"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-013-9586-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170744"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2013.11.014"},{"key":"e_1_2_10_14_1","first-page":"1285","article-title":"The mucopolysaccharidoses: characterization by cranial MR imaging","volume":"14","author":"Lee C","year":"1993","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1098"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-011-9317-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2393050459"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2017.09.006"}],"container-title":["JIMD Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.12212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmd2.12212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.12212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:41:33Z","timestamp":1693366893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmd2.12212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,21]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/jmd2.12212"],"URL":"https:\/\/doi.org\/10.1002\/jmd2.12212","archive":["Portico"],"relation":{},"ISSN":["2192-8312","2192-8312"],"issn-type":[{"value":"2192-8312","type":"print"},{"value":"2192-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,21]]},"assertion":[{"value":"2020-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}