{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T18:41:13Z","timestamp":1767724873155,"version":"build-2238731810"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Early treatment of neonatal diabetes with sulfonylureas has been proven to produce marked improvements of neurodevelopment, beside the demonstrated efficacy on glycemic control. Several barriers still prevent an early treatment in preterm babies including the limited availability of suitable galenic form of glibenclamide. We adopted oral glibenclamide suspension (Amglidia) for the early treatment of neonatal diabetes due to an homozygous variant of KCNJ11 gene c.10C&gt;T [p.Arg4Cys] in an extremely preterm infant born at 26\u2009+\u20092\u2009weeks' of gestational age. After ~6\u2009weeks of insulin treatment with a low glucose intake (4.5\u2009g\/kg\/day), the infant was switched to Amglidia 6\u2009mg\/ml diluted in maternal milk, via nasogastric tube (0.2\u2009mg\/kg\/day) progressively reduced to 0.01\u2009mg\/kg\/day (after ~3\u2009months). While on glibenclamide, the patient exhibited a mean daily growth of 11\u2009g\/kg\/day. The treatment was suspended at month 6 of birth (weight 4.9\u2009kg [5th\u201310th centile], M3 of c.a.) for normalization of glucose profile. During the treatment, the patient exhibited a stable glucose profile within the range of 4\u20138\u2009mmol\/L in the absence of hypo or hyperglycemic episodes with 2\u20133 blood glucose tests per day. The patient was diagnosed with retinopathy of prematurity Stade II in Zone II without plus disease at 32\u2009weeks, with progressive regression and complete retinal vascularization at 6\u2009months of birth. Amglidia could be regarded as the specific treatment for neonatal diabetes even in preterm babies due to its beneficial effect on the metabolic and neurodevelopmental side.<\/jats:p>","DOI":"10.1002\/jmd2.12358","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T23:59:05Z","timestamp":1675036745000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8885-3056","authenticated-orcid":false,"given":"Alfonso","family":"Galderisi","sequence":"first","affiliation":[{"name":"H\u00f4pital Universitaire Necker\u2010Enfants Malades, Service d'endocrinologie Gyn\u00e9cologie et Diab\u00e9tologie P\u00e9diatrique H\u00f4pital Necker\u2010Enfants Malades Paris  France"},{"name":"Department of Woman and Child's Health University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Kermorvant\u2010Duchemin","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine H\u00f4pital Universitaire \u2010 Enfants Malades, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Inserm, Centre de Recherche des Cordeliers, Sorbonne University Paris Cit\u00e9 University, Physiopathology of Ocular Diseases: Therapeutic Innovations  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Daruich","sequence":"additional","affiliation":[{"name":"Inserm, Centre de Recherche des Cordeliers, Sorbonne University Paris Cit\u00e9 University, Physiopathology of Ocular Diseases: Therapeutic Innovations  Paris France"},{"name":"Ophthalmology Department Necker\u2010Enfants Malades University Hospital, Assistance Publique H\u00f4pitaux de Paris, Paris Cit\u00e9 University  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline Alice","family":"Bonnard","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique H\u00f4pital Universitaire Robert Debr\u00e9  Paris France"},{"name":"INSERM UMR_S1131 \u2010 Institut de Recherche Saint\u2010Louis  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire Necker\u2010Enfants Malades, Service de P\u00e9diatrie et R\u00e9animation N\u00e9onatales Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010St\u00e9phanie","family":"Aubelle","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit of Port\u2010Royal APHP. 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Centre \u2010 Universit\u00e9 Paris Cit\u00e9, APHP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoann","family":"Vial","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique H\u00f4pital Universitaire Robert Debr\u00e9  Paris France"},{"name":"INSERM UMR_S1131 \u2010 Institut de Recherche Saint\u2010Louis  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e9ne","family":"Cave","sequence":"additional","affiliation":[{"name":"D\u00e9partement de G\u00e9n\u00e9tique H\u00f4pital Universitaire Robert Debr\u00e9  Paris France"},{"name":"INSERM UMR_S1131 \u2010 Institut de Recherche Saint\u2010Louis  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Berdugo","sequence":"additional","affiliation":[{"name":"Inserm, Centre de Recherche des Cordeliers, Sorbonne University Paris Cit\u00e9 University, Physiopathology of Ocular Diseases: Therapeutic Innovations  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Henri","family":"Jarreau","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit of Port\u2010Royal APHP. 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