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End\u2010stage kidney disease is a long\u2010term complication. Treatments include vitamin B12 supplementation, L\u2010carnitine, and a low\u2010protein diet. Liver, kidney, or combined liver\u2010kidney transplantations are promising options, but they are not without complications. We report a patient suffering from MMA cblB who developed end\u2010stage kidney disease at 18\u2009years of age. Kidney transplantation allowed him to recover normal kidney function and good metabolic control. Unfortunately, after two decades, he developed non\u2010Hodgkin lymphoma and severe chemotherapy toxicity which led to his death. The risk of lymphoproliferative diseases is known to increase after solid organ transplantation. However, in MMA, factors including mitochondrial dysfunction and oncometabolites, may further increase the risk of malignancy and drug toxicity. Our report highlights the importance of considering the increased risk of cancer in long\u2010term follow\u2010up of MMA cblB patients, especially after solid organ transplantation. Moreover, when chemotherapy is needed, the increased risk of toxicity and metabolic decompensation should be considered and monitored.<\/jats:p>","DOI":"10.1002\/jmd2.12411","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T05:48:55Z","timestamp":1704952135000},"page":"56-62","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>Non\u2010Hodgkin<\/scp> lymphoma in a kidney transplanted patient with methylmalonic acidemia: Metabolic susceptibility and the role of immunosuppression"],"prefix":"10.1002","volume":"65","author":[{"given":"Alberto B.","family":"Burlina","sequence":"first","affiliation":[{"name":"Division of Inherited Metabolic Diseases, Department of Women's and Children's Health University Hospital of Padua  Padua Italy"},{"name":"Division of Inherited Metabolic Diseases, Department of Women's and Children's Health University of Padua  Padua 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