{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:23:00Z","timestamp":1771662180495,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha\u2010fetoprotein and carcino\u2010embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des\u2010gamma\u2010carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.<\/jats:p>","DOI":"10.1002\/jmd2.12414","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T04:49:24Z","timestamp":1717044564000},"page":"207-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Screening and surveillance of hepatocellular carcinoma by serum des\u2010gamma\u2010carboxy prothrombin in patients with glycogen storage disease type Ia"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5808","authenticated-orcid":false,"given":"A. B.","family":"Schreuder","sequence":"first","affiliation":[{"name":"Department of Metabolic Diseases, Beatrix Children's Hospital University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Overduin","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases, Beatrix Children's Hospital University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. C.","family":"Peltenburg","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases and internal medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases, Amalia Children's Hospital Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. A. J. A.","family":"Bodewes","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hepatology and Gastroenterology, Beatrix Children's Hospital University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. G. J.","family":"Derks","sequence":"additional","affiliation":[{"name":"Department of Metabolic Diseases, Beatrix Children's Hospital University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1","article-title":"Glycogen storage disease type I","author":"Bali DS","year":"2021","journal-title":"GeneReviews\u00ae"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEPR.2022.100512"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00431\u2010002\u20101016\u20107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/GIM.2014.128"},{"issue":"19","key":"e_1_2_11_6_1","first-page":"2489","article-title":"Use of serum PIVKA\u2010II (DCP) determination for differentiation between benign and malignant liver diseases","author":"Lamerz R","year":"1999","journal-title":"Anticancer Res"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346080"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00261\u2010011\u20109721\u20101"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/PED.14202"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12610"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198405313102204"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003448"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.043364"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/LIV.13031"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2015.10.008"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JHEP.2018.07.017"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/HUM.2017.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12056"}],"container-title":["JIMD Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.12414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T06:34:56Z","timestamp":1720161296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmd2.12414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,29]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/jmd2.12414"],"URL":"https:\/\/doi.org\/10.1002\/jmd2.12414","archive":["Portico"],"relation":{},"ISSN":["2192-8312","2192-8312"],"issn-type":[{"value":"2192-8312","type":"print"},{"value":"2192-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,29]]},"assertion":[{"value":"2023-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}