{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:21Z","timestamp":1747149741112,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neuronal ceroid lipofuscinosis type 2 (CLN2) is a heterogeneous group of neurodegenerative lysosomal storage disorders caused by autosomal recessive inheritance of two pathogenic variants in trans in the <jats:italic>TPP1<\/jats:italic> gene. Classical late\u2010infantile CLN2 disease has a very well\u2010defined natural history. However, a small number of patients with TPP1 enzyme deficiency present a later onset or protracted disease course within this group there are phenotypic variants. Our work aimed to identify pathological variants in the <jats:italic>TPP1<\/jats:italic> gene that conditioned the development of CLN2 disease in Ukrainian patients, to compare these variants with those found in patients from other European and non\u2010European regions, and to make genotype\u2013phenotype associations for this disease. The phenotypes and genotypes of the 48 CLN2\u2010affected individuals belonging to 43 families were profiled through clinical data collection, enzyme analysis, and genotyping. In most patients, genotype and phenotype correlation are in keeping with the data of previous studies. The clinical signs of the disease in patients with new, previously undescribed variants, allowed us to augment existing data about genotype\u2013phenotype correlations for CLN2 disease. The combination of genotype and clinical form of the disease demonstrated that predicting the type and clinical course of the disease based on genotype is very complicated. The data we obtained supplements existing information on genotype\u2013phenotypic correlations in this rare disease, which, in turn, lays the foundation for a personalized approach to the management of this disease.<\/jats:p>","DOI":"10.1002\/jmd2.12423","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T07:44:05Z","timestamp":1715672645000},"page":"272-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The neuronal ceroid lipofuscinosis type 2 \u2013 associated variants: An analysis of alterations in the <i>TPP1<\/i> gene and genotype\u2013phenotype correlation in Ukraine"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-2782","authenticated-orcid":false,"given":"Nataliia","family":"Olkhovych","sequence":"first","affiliation":[{"name":"Department of Genetic Diagnostics National Scientific Center, Institute of Cardiology, Clinical and 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