{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:33:06Z","timestamp":1779136386744,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Familial chylomicronemia syndrome (FCS) is a rare inherited disorder characterized by severe hypertriglyceridemia, posing a heightened risk of acute pancreatitis. Recently, Volanesorsen, an APOC3 antisense oligonucleotide, gained approval for FCS treatment in the UK. Caution is advised during pregnancy due to limited safety data, although animal studies show no toxicity\/teratogenicity. Two case scenarios are presented: In the first case, a patient with FCS continued Volanesorsen injections without having thrombocytopenia during an unplanned pregnancy until third trimester, maintaining triglyceride control. Upon discovering the pregnancy at 38\u2009weeks, Volanesorsen was ceased, and a low\u2010fat diet reinstated. Despite a heightened risk of pancreatitis, no episodes of pancreatitis occurred during the pregnancy. In the second case, stopping Volanesorsen before conception led to elevated triglycerides, and an episode of acute pancreatitis at 22\u2009weeks, despite strict very low\u2010fat diet and fibrate therapy from 14\u2009weeks. At 23\u2009weeks, Volanesorsen was reintroduced concurrently with regular therapeutic plasma exchange. No further episodes of pancreatitis occurred. In both case, fetal health was maintained throughout pregnancy, fetal scans revealed no anomalies, and planned C\u2010sections delivered healthy babies without congenital issues. Both babies are well and developing normally at 24 and 19\u2009months.<\/jats:p>","DOI":"10.1002\/jmd2.12435","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T03:03:36Z","timestamp":1718593416000},"page":"249-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Two successful pregnancies \u2010in patients taking\u00a0Volanesorsen for familial chylomicronemia syndrome"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2812-4748","authenticated-orcid":false,"given":"Subadra","family":"Wanninayake","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ochoa\u2010Ferraro","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karishma","family":"Patel","sequence":"additional","affiliation":[{"name":"The Grantham Practice  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radha","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Adult Inherited Metabolic Diseases, Metabolic Medicine and Chemical Pathology Guys and St Thomas' Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony S.","family":"Wierzbicki","sequence":"additional","affiliation":[{"name":"Department of Adult Inherited Metabolic Diseases, Metabolic Medicine and Chemical Pathology Guys and St Thomas' Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-6468","authenticated-orcid":false,"given":"Charlotte","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.06.814"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2018.05.013"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.593931"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1180-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3663079"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S224771"},{"key":"e_1_2_12_8_1","volume-title":"Use of Medicines in Pregnancy and Breastfeeding","author":"Agency, M.H.P.R","year":"2021"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-020-00836-w"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2019.0837"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-020-09677-1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2020.100159"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002160"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2020.151221"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semperi.2020.151227"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.08.003"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.087395"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00336.x"},{"key":"e_1_2_12_19_1","volume-title":"Medicines in Pregnancy and Breastfeeding: New Initiative for Consistent Guidance; Report on Optimising Data for Medicines Used during Pregnancy","author":"Agency, M.H.P.R","year":"2021"},{"key":"e_1_2_12_20_1","volume-title":"International Non\u2010proprietary Name: Volanesorsen","author":"(CHMP), C.f.M.P.f.H.U","year":"2019"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.03.018"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000436438.60145.5a"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.10.025"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.02.005"},{"issue":"2","key":"e_1_2_12_25_1","first-page":"85","article-title":"Acute pancreatitis in pregnancy","volume":"61","author":"Chang CC","year":"1998","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199504000-00005"}],"container-title":["JIMD Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.12435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T06:34:28Z","timestamp":1720161268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmd2.12435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,16]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/jmd2.12435"],"URL":"https:\/\/doi.org\/10.1002\/jmd2.12435","archive":["Portico"],"relation":{},"ISSN":["2192-8312","2192-8312"],"issn-type":[{"value":"2192-8312","type":"print"},{"value":"2192-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,16]]},"assertion":[{"value":"2024-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}