{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:34Z","timestamp":1753869454874,"version":"3.41.2"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>SARS\u2010CoV\u20102 infection and Long COVID (LC) might lead to a significant deterioration of physical and mental health. Wilson disease (WD) patients have a chronic liver and\/or neuropsychiatric disease, making it particularly interesting to investigate LC in WD. 51 WD patients were retrospectively examined, evaluating physical and mental health by a survey and neuropsychological tests (SF\u201012, PSQI, ISI, Epworth, Chalder\u2010fatigue scale, PHQ\u20109, GAD\u20107, PSS, FLei) before and ~11\u2009months after SARS\u2010CoV\u20102 infection. LC was defined as the development of new, at least moderately severe symptoms (shortness of breath, chest pain, fatigue, brain fog, exercise capacity, concentration disturbances) and\/or worsening of pre\u2010existing symptoms. 70.6% had predominant hepatic and 29.4% had neuropsychiatric symptoms at WD diagnosis. Median age was 39\u2009years; 56.1% were female. Patients were in stable maintenance phase with a median treatment duration of 23\u2009years. When compared to before COVID\u201019, WD patients had significantly worse physical life quality, sleeping quality, and fatigue. After COVID\u201019, a high percentage of WD patients reported concentration disorders (60%), fatigue (55%), reduced exercise capacity (50%), shortness of breath (40%), chest pain (20%) and feeling of brain fog (15%). 39.2% (<jats:italic>n<\/jats:italic>\u2009=\u200920) of the WD patients were classified as LC. This LC\u2010WD subgroup showed significantly impaired quality of life, a high stress level, and sleeping disturbances, fatigue, depression, anxiety, and cognitive impairment. A large proportion of WD patients experience LC symptoms, reduced life quality, and sleeping disorders after SARS\u2010CoV\u20102 infection. WD patients post\u2010infection should be well monitored and supported if they develop persisting symptoms or neuro\u2010psychological problems.<\/jats:p>","DOI":"10.1002\/jmd2.70021","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T03:24:57Z","timestamp":1746588297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mental and Physical Health in Wilson Disease Patients With <scp>SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102 Infection and Relevance of Long\u2010<scp>COVID<\/scp>"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-0241","authenticated-orcid":false,"given":"Isabelle","family":"Mohr","sequence":"first","affiliation":[{"name":"Internal Medicine IV, Department of Gastroenterology University Hospital Heidelberg  Heidelberg 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