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The main risk of persistent chylomicronemia is acute pancreatitis (AP). During the second and third trimester of pregnancy, TG levels significantly increase, which represents a serious risk of AP in women with preexisting chylomicronemia. New emerging therapies such as plozasiran, a GalNAc\u2010conjugated small interfering RNA (siRNA) against ApoC3, are developed to manage persistent chylomicronemia, but no data are currently available on their safety and efficacy during pregnancy. We report herein the case of a woman with persistent chylomicronemia randomized in the PALISADE study to receive plozasiran 25\u2009mg quarterly, who had an unplanned pregnancy during the clinical trial. The 34\u2010year\u2010old patient received one dose of plozasiran 8\u2009weeks before conception and the experimental treatment was ceased afterwards. The pregnancy went well, TG levels did not rise above 10\u2009mmol\/L (880\u2009mg\/dL) during the whole pregnancy, even during the last two trimesters where TG levels usually increase two\u2010 to four\u2010fold from baseline and she did not experience any AP episode. She delivered a healthy baby at 39\u2009weeks. This case suggests that plozasiran might be safe for the mother and the fetus and could prevent incremental pregnancy\u2010driven TG elevation and occurrence of AP in women with sHTG. This is consistent with the long duration of action and hepatic half\u2010life of plozasiran in clinical studies where TG levels remained sustainably lower than baseline &gt;\u20099\u2009months after the last injection.<\/jats:p>","DOI":"10.1002\/jmd2.70052","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T23:54:37Z","timestamp":1764892477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Course of Pregnancy in a Woman With Familial Chylomicronemia Syndrome Treated With Plozasiran, a Small Interfering\n                    <scp>RNA<\/scp>\n                    Against\n                    <scp>ApoC3<\/scp>"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2356-5396","authenticated-orcid":false,"given":"Miriam","family":"Larouche","sequence":"first","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al and ECOGENE\u201021  Chicoutimi Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Brisson","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al and ECOGENE\u201021  Chicoutimi Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al and ECOGENE\u201021  Chicoutimi Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudy","family":"Grenon","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al and ECOGENE\u201021  Chicoutimi Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Poirier","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e9 Laval  Quebec City Canada"},{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec, Universit\u00e9 Laval  Quebec City Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma'an","family":"Muhsin","sequence":"additional","affiliation":[{"name":"Arrowhead Pharmaceuticals, Inc.  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gaudet","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 de Montr\u00e9al and ECOGENE\u201021  Chicoutimi Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02069-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000980"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.745"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab551"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000903"},{"issue":"4","key":"e_1_2_10_7_1","first-page":"723","article-title":"Recognition and Management of Persistent Chylomicronemia: A Joint Expert Clinical Consensus by the National Lipid Association and the American Society for Preventive Cardiology","volume":"19","author":"Saadatagah S.","year":"2025","journal-title":"Journal of Clinical Lipidology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2025.03.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2025.02.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00455"},{"key":"e_1_2_10_11_1","first-page":"S14","article-title":"Comparison of Patients With Familial Chylomicronemia Syndrome and Multifactorial Chylomicronemia Syndrome","volume":"48","author":"Spagnuolo C. 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J.Larouche Miriam B.Diane L.Nathalie et\u00a0al. \u201cGaudet Daniel Acute Pancreatitis During Pregnancy in Women with Chylomicronemia \u201din93rd Congress European Atherosclerosis Society Acute Pancreatitis During Pregnancy in Women With Chylomicronemia Glasgow (2025).","DOI":"10.1016\/j.atherosclerosis.2025.119612"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722173"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(02)00283-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1250"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108677"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-70178-3_12"},{"issue":"6","key":"e_1_2_10_21_1","first-page":"677","article-title":"Hypertriglyceridemia\u2010Induced Acute Pancreatitis in Pregnancy","volume":"13","author":"Serpytis M.","year":"2012","journal-title":"Journal of the Pancreas"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2016.59.2.148"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000334"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.11.028"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.08.008"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.67.794.1062"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21705"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2021.103346"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2786-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(25)00028-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2409368"},{"key":"e_1_2_10_32_1","volume-title":"The Online Metabolic and Molecular Bases of Inherited Disease","author":"Brunzell J. 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