{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:48:28Z","timestamp":1782434908113,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Wilson disease (WD) is a rare autosomal recessive disorder. Although hepatic and neurologic manifestations are characterized, long\u2010term cardiac outcomes remain poorly defined. We report the first longitudinal study systematically assessing cardiac symptoms and events over nearly a decade in WD. In 2016, 61 WD patients underwent prospective cardiac evaluation including echocardiography, MRI and 24\u2010h ECG. Nine years later, we re\u2010contacted all surviving participants by telephone and emailed standardized questionnaires. Baseline characteristics of respondents and non\u2010respondents were compared to assess selection bias; mortality data were obtained from family interviews and medical records. Outcomes were available for 31 of 61 patients (27 interviewed, 4 deceased; no cardiac\u2010related deaths) after a mean follow\u2010up of 9.1\u2009years. Respondents did not differ from those lost to follow\u2010up, except for fewer disease exacerbations. General and cardiac health remained unchanged in about half (48% and 52%), worsened in ~40%, and improved in \u2264\u200915%. Palpitations were frequent (70%), whereas dizziness (26%), syncope (7%), and leg oedema (15%) were infrequent and comparable to general\u2010population estimates. Daily activity was unrestricted in 44%, mildly to moderately restricted in 52% and severely restricted in 4%. Only six patients (22%) remained in routine cardiology care. Baseline imaging, strain, autonomic and laboratory parameters did not predict symptoms at follow\u2010up. Over 9\u2009years, cardiac symptoms in WD were common but mostly mild to moderate. These findings support a symptom\u2010guided cardiological assessment within interdisciplinary care. Whether systematic screening of asymptomatic patients is warranted remains uncertain and requires dedicated prospective study.<\/jats:p>","DOI":"10.1002\/jmd2.70106","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:21:51Z","timestamp":1782433311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Manifestation in Wilson Disease: Results of a 9\u2010Year Prospective Cohort"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-4790","authenticated-orcid":false,"given":"S.","family":"Quick","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Angiology and Intensive Care, Klinikum Chemnitz gGmbH Medical Campus Chemnitz of the TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cybularz\u2010Bednarek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Herzzentrum Dresden TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Angiology and Intensive Care, Klinikum Chemnitz gGmbH Medical Campus Chemnitz of the TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care Medicine Deutsches Herzzentrum der Charit\u00e9  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Angiology and Intensive Care, Klinikum Chemnitz gGmbH Medical Campus Chemnitz of the TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Christoph","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Angiology and Intensive Care, Klinikum Chemnitz gGmbH Medical Campus Chemnitz of the TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Cardiology, Angiology and Intensive Care, Klinikum Chemnitz gGmbH Medical Campus Chemnitz of the TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Linke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Herzzentrum Dresden TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1972-8216","authenticated-orcid":false,"given":"F. M.","family":"Heidrich","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Herzzentrum Dresden TUD Dresden University of Technology  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"3","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0031-1286056","article-title":"Wilson Disease: Pathogenesis and Clinical Considerations in Diagnosis and Treatment","volume":"31","author":"Rosencrantz R.","year":"2011","journal-title":"Seminars in Liver Disease"},{"issue":"1","key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00428430","article-title":"Secondary Athrocytotic Cardiomyopathy\u2014Heart Damage due to Wilson's Disease","volume":"387","author":"Kaduk B.","year":"1980","journal-title":"Virchows Archiv A, Pathological Anatomy and Histology"},{"issue":"3","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00496571","article-title":"The Cardiomyopathy of Wilson's Disease. Myocardial Alterations in Nine Cases","volume":"397","author":"Factor S. M.","year":"1982","journal-title":"Virchows Archiv A, Pathological Anatomy and Histology"},{"issue":"22","key":"e_1_2_14_5_1","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1016\/j.jacc.2018.08.2197","article-title":"Cardiac Manifestation of Wilson's Disease","volume":"72","author":"Quick S.","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"e_1_2_14_6_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13023-019-1007-7","article-title":"Cardiac and Autonomic Function in Patients With Wilson's Disease","volume":"14","author":"Quick S.","year":"2019","journal-title":"Orphanet Journal of Rare Diseases"},{"issue":"11","key":"e_1_2_14_7_1","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.amjcard.2017.08.025","article-title":"Wilson's Disease and Cardiac Myopathy","volume":"120","author":"Grandis D. J.","year":"2017","journal-title":"American Journal of Cardiology"},{"key":"e_1_2_14_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanepe.2023.100786","article-title":"Atrial Fibrillation: Epidemiology, Screening and Digital Health","volume":"37","author":"Linz D.","year":"2024","journal-title":"Lancet Regional Health"},{"issue":"6","key":"e_1_2_14_9_1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/s00415-005-0720-4","article-title":"Wilson's Disease\u2014Cause of Mortality in 164 Patients During 1992\u20102003 Observation Period","volume":"252","author":"Cz\u0142onkowska A.","year":"2005","journal-title":"Journal of Neurology"},{"issue":"1","key":"e_1_2_14_10_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-018-0018-3","article-title":"Wilson Disease","volume":"4","author":"Cz\u0142onkowska A.","year":"2018","journal-title":"Nature Reviews Disease Primers"},{"issue":"1","key":"e_1_2_14_11_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ehf2.12395","article-title":"Cardiac Arrest in Wilson's Disease After Curative Liver Transplantation: A Life\u2010Threatening Complication of Myocardial Copper Excess?","volume":"6","author":"Bobbio E.","year":"2019","journal-title":"ESC Heart Failure"},{"issue":"5","key":"e_1_2_14_12_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/jimd.12418","article-title":"Cardiac Involvement in Wilson Disease: Review of the Literature and Description of Three Cases of Sudden Death","volume":"44","author":"Chevalier K.","year":"2021","journal-title":"Journal of Inherited Metabolic Disease"},{"issue":"4","key":"e_1_2_14_13_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1378\/chest.91.4.579","article-title":"Cardiac Wilson's Disease","volume":"91","author":"Kuan P.","year":"1987","journal-title":"Chest"},{"key":"e_1_2_14_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpg.2021.101768","article-title":"Wilson's Disease\u2014Management and Long Term Outcomes","volume":"56","author":"Socha P.","year":"2022","journal-title":"Best Practice & Research. Clinical Gastroenterology"},{"issue":"2","key":"e_1_2_14_15_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jceh.2021.05.013","article-title":"Quality of Life of Patients With Wilson's Disease and Their Families","volume":"12","author":"Unavane O.","year":"2022","journal-title":"Journal of Clinical and Experimental Hepatology"},{"issue":"1","key":"e_1_2_14_16_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/gut.2005.087262","article-title":"Clinical Presentation, Diagnosis and Long\u2010Term Outcome of Wilson's Disease: A Cohort Study","volume":"56","author":"Merle U.","year":"2007","journal-title":"Gut"},{"issue":"2","key":"e_1_2_14_17_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0002-9343(97)89451-X","article-title":"Evaluation and Outcomes of Patients With Palpitations","volume":"100","author":"Weber B. 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S.","year":"2018","journal-title":"Journal of Ayub Medical College, Abbottabad"},{"issue":"1","key":"e_1_2_14_26_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12968-021-00760-1","article-title":"The Impact of Wilson Disease on Myocardial Tissue and Function: A Cardiovascular Magnetic Resonance Study","volume":"23","author":"Salatzki J.","year":"2021","journal-title":"Journal of Cardiovascular Magnetic Resonance"},{"issue":"8","key":"e_1_2_14_27_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-030808","article-title":"Review of Response Rates Over Time in Registry\u2010Based Studies Using Patient\u2010Reported Outcome Measures","volume":"10","author":"Wang K.","year":"2020","journal-title":"BMJ Open"},{"issue":"4","key":"e_1_2_14_28_1","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/jcop.22932","article-title":"Locating Longitudinal Study Participants 10\u2009Years After Last Contact: Contemporary Approaches to Sample Retention","volume":"51","author":"Dimakos C.","year":"2023","journal-title":"Journal of Community Psychology"}],"container-title":["JIMD Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.70106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmd2.70106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.70106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:21:55Z","timestamp":1782433315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmd2.70106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/jmd2.70106"],"URL":"https:\/\/doi.org\/10.1002\/jmd2.70106","archive":["Portico"],"relation":{},"ISSN":["2192-8312","2192-8312"],"issn-type":[{"value":"2192-8312","type":"print"},{"value":"2192-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"2026-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70106"}}