{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:59:57Z","timestamp":1790593197404,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","award":["17\u20104215"],"award-info":[{"award-number":["17\u20104215"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["10\u2010002136"],"award-info":[{"award-number":["10\u2010002136"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010346","name":"Else og Mogens Wedell Wedellsborgs Fond","doi-asserted-by":"publisher","award":["6\u201018\u20101"],"award-info":[{"award-number":["6\u201018\u20101"]}],"id":[{"id":"10.13039\/501100010346","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["JIMD Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mitochondrial myopathy (MM) represents a group with a broad phenotypic spectrum which complicates the diagnostic process. This study investigated whether plasma lactate changes following a 12\u2010min walk test (12MWT) and 20\u2010min recovery could be a diagnostic screening tool for MM. Thirty patients with MM and 19 healthy controls (HC) participated. Total walking distance and heart rate during the test were measured, along with plasma lactate at rest, after exercise, and during recovery. For the latter, we calculated the area under the curve (AUC). The results were compared between groups. MM patients walked shorter (1082\u2009m [994\u20131143] m vs. 1349\u2009m [1149\u20131435],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0005) and had higher resting lactate (1.7\u2009\u00b1\u20091.2\u2009mmol\/L vs. 0.9\u2009\u00b1\u20090.3\u2009mmol\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003). No significant difference in plasma lactate was observed after exercise. Plasma lactate AUC during recovery was similar between groups. Thus, the 12MWT is not a reliable screening tool for MM as changes in plasma lactate during exercise and recovery did not differentiate MM from HC.\n                  <\/jats:p>","DOI":"10.1002\/jmd2.70112","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:18:47Z","timestamp":1787876327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Lactate Response to a 12\u2010Min Walk Test Is a Poor Diagnostic Biomarker for Mitochondrial Myopathy"],"prefix":"10.1002","volume":"67","author":[{"given":"Christine","family":"Lando","sequence":"first","affiliation":[{"name":"Copenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmina","family":"Khawajazada","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Helbo","family":"Storgaard","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna Scharff","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vissing","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-8484","authenticated-orcid":false,"given":"Nicoline","family":"L\u00f8kken","sequence":"additional","affiliation":[{"name":"Copenhagen Neuromuscular Center, Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae041"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4809"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-00674-4"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0987-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","unstructured":"T. D.Jensen P.Kazemi\u2010Esfarjani E.Skomorowska andJ.Vissing \u201cA Forearm Exercise Screening Test for Mitochondrial Myopathy \u201d 2002.","DOI":"10.1212\/WNL.58.10.1533"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10027"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2021.07.002"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-003-0993-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074981"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(01)00371-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100001712"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00170-1"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20101331.2004.00859.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","unstructured":"R.Dandurand P. M.Matthews D. L.Arnold andD. H.Eidelman \u201cMitochondrial Disease* Pulmonary Function Exercise Performance and Blood Lactate Levels \u201d 1995.","DOI":"10.1378\/chest.108.1.182"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg028"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2004.07.011"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1366\/14-07604"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","unstructured":"K. L.Madsen A. E.Buch B. H.Cohen et\u00a0al. \u201cSafety and Efficacy of Omaveloxolone in Patients With Mitochondrial Myopathy MOTOR Trial \u201d 2020.","DOI":"10.1212\/WNL.0000000000008861"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12559"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010022\u201011324\u20103"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207402"}],"container-title":["JIMD Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.70112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmd2.70112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmd2.70112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:16:42Z","timestamp":1790590602000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmd2.70112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jmd2.70112"],"URL":"https:\/\/doi.org\/10.1002\/jmd2.70112","archive":["Portico"],"relation":{},"ISSN":["2192-8312","2192-8312"],"issn-type":[{"value":"2192-8312","type":"print"},{"value":"2192-8312","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"assertion":[{"value":"2025-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70112"}}