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The transitional point in the inner layer between the central and the marginal parts was well marked. This is evidently due to the extreme growth inhibition of the inner layer at the marginal part.<\/jats:p><jats:p>At the early developmental stage, an area of the inner layer corresponding to the transitional point protruded toward the lens because the central part of the inner layer continued to differentiate.<\/jats:p><jats:p>The differentiation and the protrusion of the inner layer proceeded variably at the later stages depending on the degree of the growth inhibition. The eyes were classified into three groups: Group A\u2013the retina was recognized as a cyst consisting of the pigment layer and the pigment\u2010layerlike structure which originated from the inner layer; group B\u2010the neural retina and its layered structure were inverted; group C\u2010abnormalities, such as the destruction of the lens, were observed.<\/jats:p><jats:p>Although previous authors who studied eye mutants suggested the vascular abnormality as the primary cause of the production of abnormal eyes, we feel that this is not the case in our animals.<\/jats:p>","DOI":"10.1002\/jmor.1051670302","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T18:22:02Z","timestamp":1109269322000},"page":"265-276","source":"Crossref","is-referenced-by-count":27,"title":["Morphogenesis of the hereditary microphthalmia in a new strain of rat"],"prefix":"10.1002","volume":"167","author":[{"given":"Kenji","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Otani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.22.10.613"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001270305"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.132.3419.89-a"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051090104"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1943.00880210062006"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050680205"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401330202"},{"key":"e_1_2_1_9_1","volume-title":"System of Ophthalmology","author":"Duke\u2010Elder S","year":"1964"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(74)90030-X"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(78)90139-2"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1959.39.1.69"},{"key":"e_1_2_1_13_1","first-page":"187","article-title":"Developmental genetical studies on genetic malformations in laboratory animals","volume":"27","author":"Kameyama Y.","year":"1976","journal-title":"Ann. 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