{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:34:27Z","timestamp":1780108467467,"version":"3.54.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T00:00:00Z","timestamp":1317168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Morphology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult urodele amphibians possess extensive regenerative abilities, including lens, jaws, limbs, and tails. In this study, we examined the cellular events and time course of spinal cord regeneration in a species, <jats:italic>Plethodon cinereus<\/jats:italic>, that has the ability to autotomize its tail as an antipredator strategy. We propose that this species may have enhanced regenerative abilities as further coadaptations with this antipredator strategy. We examined the expression of nestin, vimentin, and glial fibrillary acidic protein (GFAP) after autotomy as markers of neural precursor cells and astroglia; we also traced the appearance of new neurons using 5\u2010bromo\u20102\u2032\u2010deoxyuridine\/neuronal nuclei (BrdU\/NeuN) double labeling. As expected, the regenerating ependymal tube was a major source of new neurons; however, the spinal cord cranial to the plane of autotomy showed significant mitotic activity, more extensive than what is reported for other urodeles that cannot autotomize their tails. In addition, this species shows upregulation of nestin, vimentin, and GFAP within days after tail autotomy; further, this expression is upregulated within the spinal cord cranial to the plane of autotomy, not just within the extending ependymal tube, as reported in other urodeles. We suggest that enhanced survival of the spinal cord cranial to autotomy allows this portion to participate in the enhanced recovery and regeneration of the spinal cord. J. Morphol. 2011. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/jmor.11019","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T12:32:54Z","timestamp":1317213174000},"page":"211-225","source":"Crossref","is-referenced-by-count":17,"title":["Spinal cord regeneration in a tail autotomizing urodele"],"prefix":"10.1002","volume":"273","author":[{"given":"Ellen M.","family":"Dawley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"O. Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton T.","family":"Woodard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Matthias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402640307"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199705)209:1<15::AID-AJA2>3.0.CO;2-#"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004270050265"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10240"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.04-08-02080.1984"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490060608"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10224"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401990202"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-13-05046.1997"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80783-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1278"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(72)90085-4"},{"key":"e_1_2_6_14_1","first-page":"650","volume-title":"Neuroglia","author":"Eng LF","year":"1995"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10226"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1523\/JNEUROSCI.08-04-01144.1988","article-title":"Proliferation and differentiation of rat neuroepithelial precursor cells in vivo","volume":"8","author":"Fredericksen K","year":"1988","journal-title":"J Neurosci"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-28-09357.2003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01189811"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-12-03310.1985"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90151-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01186819"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-06-02218.2000"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401960303"},{"key":"e_1_2_6_24_1","first-page":"426","volume-title":"Adult Neurogenesis: Stem Cells and Neuronal Development in the Adult Brain","author":"Kempermann G","year":"2006"},{"key":"e_1_2_6_25_1","first-page":"187","article-title":"Glial fibrillary acidic protein and vimentin in radial glial of Ambystoma mexicanum and Triturus carnifex: In immunocytochemical study","volume":"38","author":"Lazzari M","year":"1997","journal-title":"J Brain Res"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20354"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02852"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.10.001"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116.1.201"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199905000-00008"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90849-4"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10236"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001930202"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-01-00208.1986"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-18-07153.2001"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20288"},{"key":"e_1_2_6_37_1","first-page":"68","article-title":"An immunofluorescent microscopical study of the neurofilament triplet proteins, vimentin, and glial fibrillary acidic protein within the adult rat brain","volume":"26","author":"Shaw G","year":"1981","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1523\/JNEUROSCI.14-01-00124.1994","article-title":"Molecular plasticity of adult Bergmann fibers is associated with radial migration of grafted Purkinje cells","volume":"14","author":"Sotelo C","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(81)90313-4"},{"key":"e_1_2_6_40_1","first-page":"303","article-title":"Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells","volume":"66","author":"Tohyama T","year":"1992","journal-title":"Lab Inves"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051220402"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00427-003-0364-2"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4144-6"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90237-0"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10230"}],"container-title":["Journal of Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmor.11019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmor.11019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T04:52:45Z","timestamp":1700542365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmor.11019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,28]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1002\/jmor.11019"],"URL":"https:\/\/doi.org\/10.1002\/jmor.11019","archive":["Portico"],"relation":{},"ISSN":["0362-2525","1097-4687"],"issn-type":[{"value":"0362-2525","type":"print"},{"value":"1097-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,28]]}}}