{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:36:16Z","timestamp":1762252576539,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T00:00:00Z","timestamp":1500508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007070","name":"UNMdP","doi-asserted-by":"publisher","award":["EXA 765\/16"],"award-info":[{"award-number":["EXA 765\/16"]}],"id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Morphology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ascending colon of most rodent species shows a longitudinal colonic groove that works as a retrograde transport pathway for a mixture of bacteria and mucus toward the cecum. We describe the morphology and glycosylation pattern of the colonic groove of <jats:italic>Lagostomus maximus<\/jats:italic> to analyze the role of mucins in this anatomical feature. We also studied the distribution pattern of the interstitial cells of Cajal (ICC) to evaluate their regulatory influence on gut motility. The groove originated near the cecocolic junction and extended along the mesenteric side of the ascending colon, limited at both ends by nonpapillated ridges. These ridges divided the lumen of the ascending colon into two compartments: a narrow channel and a large channel, called the groove lumen and the main lumen, respectively. The histochemical analysis showed differences in the glycosylation pattern of the goblet cells inside and outside the groove. Unlike the mucosa lining the main lumen of the colon, the groove was rich in goblet cells that secrete sulfomucins. The PA\/Bh\/KOH\/PAS technique evidenced an abrupt change in the histochemical profile of goblet cells, which presented a negative reaction in the groove and a strongly positive one in the rest of the colonic mucosa. The anti\u2010c\u2010kit immunohistochemical analysis showed different ICC subpopulations in the ascending colon of <jats:italic>L. maximus<\/jats:italic>. Of all types identified, the ICC\u2010SM were the only cells located solely within the colonic groove.<\/jats:p>","DOI":"10.1002\/jmor.20735","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T05:20:44Z","timestamp":1500528044000},"page":"1606-1618","source":"Crossref","is-referenced-by-count":9,"title":["The colonic groove of the plains viscacha (<i>Lagostomus maximus<\/i>): Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells"],"prefix":"10.1002","volume":"278","author":[{"given":"Mar\u00eda Florencia","family":"Tano de la Hoz","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda Instituto de Investigaciones Marinas y Costeras (IIMyC), Universidad Nacional de Mar del Plata, CONICET, FCEyN, Funes 3250 3\u00b0 piso Mar del Plata 7600 Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta Alicia","family":"Flamini","sequence":"additional","affiliation":[{"name":"Laboratorio de Histolog\u00eda y Embriolog\u00eda Descriptiva, Experimental y Comparada, Departamento de Ciencias B\u00e1sicas, Facultad de Ciencias Veterinarias Universidad Nacional de La Plata La Plata 1900 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Natalia","family":"Zanuzzi","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  Argentina"},{"name":"Laboratorio de Histolog\u00eda y Embriolog\u00eda Descriptiva, Experimental y Comparada, Departamento de Ciencias B\u00e1sicas, Facultad de Ciencias Veterinarias Universidad Nacional de La Plata La Plata 1900 Argentina"},{"name":"Instituto de Patolog\u00eda, \u201cProf. Dr. Bernardo Epstein\u201d, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata La Plata 1900 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-7556","authenticated-orcid":false,"given":"Alcira Ofelia","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Instituto de Investigaciones Marinas y Costeras (IIMyC), Universidad Nacional de Mar del Plata, CONICET, FCEyN, Funes 3250 3\u00b0 piso Mar del Plata 7600 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"863","article-title":"Lectin histochemistry for in situ profiling of rat colon sialoglycoconjugates","volume":"23","author":"Accili D.","year":"2008","journal-title":"Histology and Histophatology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr000407m"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2005.11.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2009.00967.x"},{"key":"e_1_2_7_6_1","first-page":"275","article-title":"Colonic separation mechanism in lagomorph and rodent species\u2014A comparison","volume":"75","author":"Bj\u00f6rnhag G.","year":"1999","journal-title":"Mitteilungen Aus Dem Museum F\u00fcr Naturkunde in Berlin"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/4003548"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1139\/z94-296"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.01.013"},{"volume-title":"Institute of laboratory animals resources. Guide for the care and use of laboratory animals","year":"1996","author":"Commission on Life Sciences National Research Council","key":"e_1_2_7_10_1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2014.05.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/24.12.187689"},{"key":"e_1_2_7_13_1","first-page":"71","volume-title":"Infections of the gastrointestinal tract","author":"Forstner J. F.","year":"1995"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00418-002-0432-0","article-title":"Microbial\u2013host interactions specifically control the glycosylation pattern in intestinal mouse mucosa","volume":"118","author":"Freitas M.","year":"2002","journal-title":"Histochemistry and Cell Biology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/zoo.21216"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.11.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/3504168"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-010-0131-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.10733"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.2005.00676.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/12.4.309"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2011.12.009"},{"key":"e_1_2_7_23_1","first-page":"607","volume-title":"Histochimie et cytochimie animales. Principes et m\u00e9thodes","author":"Lison L.","year":"1953"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2007.03.003"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22146"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1635-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2007.07.003"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520294809106232"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2538"},{"key":"e_1_2_7_30_1","first-page":"45","article-title":"Feeding biology of the dassie\u2010rat Pteromus typicus in captivity","volume":"135","author":"Mess A.","year":"2005","journal-title":"Belgian Journal of Zoology"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb16654.x"},{"key":"e_1_2_7_32_1","first-page":"631 p","volume-title":"Histochemistry: Theoretical and applied","author":"Pearse A. G. E.","year":"1985"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/mamm.1998.62.2.191"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/21.5.473"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/1997\/642360"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1344-3941.2003.00124.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00006.2016"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.1999.00164.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2015.06.003"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00214387"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003600050147"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003600000131"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-005-0039-6"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-6395.2012.00577.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23335"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01680446"},{"volume-title":"Ciencia y Tecnolog\u00eda en Protecci\u00f3n y Experimentaci\u00f3n Animal","year":"2001","author":"Zu\u00f1iga M.","key":"e_1_2_7_47_1"}],"container-title":["Journal of Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmor.20735","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmor.20735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T23:22:55Z","timestamp":1696375375000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmor.20735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,20]]},"references-count":46,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/jmor.20735"],"URL":"https:\/\/doi.org\/10.1002\/jmor.20735","archive":["Portico"],"relation":{},"ISSN":["0362-2525","1097-4687"],"issn-type":[{"type":"print","value":"0362-2525"},{"type":"electronic","value":"1097-4687"}],"subject":[],"published":{"date-parts":[[2017,7,20]]}}}