{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T22:49:09Z","timestamp":1769208549887,"version":"3.49.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407106\/2018\u20109"],"award-info":[{"award-number":["407106\/2018\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["7616\/2015"],"award-info":[{"award-number":["7616\/2015"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","award":["9038\/2015"],"award-info":[{"award-number":["9038\/2015"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Morphology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Artibeus lituratus<\/jats:italic><\/jats:styled-content> is a frugivorous bat that directly assists in the restoration of degraded habitats through the effective dispersion of seeds and fruits. Given its great importance, this work aimed to evaluate the uterine hormonal control of <jats:styled-content style=\"fixed-case\"><jats:italic>A. lituratus<\/jats:italic><\/jats:styled-content> during its different reproductive phases. The uteri of 30 sexually mature adult females, five specimens for each of the six sample groups (NON, nonreproductive; P1, initial pregnancy; P2, intermediate pregnancy; P3, advanced pregnancy; LAC, lactating; P\u2009+\u2009LAC, pregnant\u2010lactating), were submitted to analyses of serum estradiol and progesterone concentrations, in addition to immunohistochemical analyses. Both estradiol and progesterone, gradually increased during pregnancy, with a marked significant increase in P3 females. Both returned to low levels in LAC\u2010females; however, estradiol levels decreased further in P\u2009+\u2009LAC\u2010females, while progesterone increased in the same group. In general, signs indicative of aromatase expression were observed in the endometrium of all analyzed groups and in the placenta of bats in the gestation groups. Similarly, ER\u03b1 and PR were expressed in the myometrium, endometrium and placenta at varying levels of intensity. The results indicate that the uterine microenvironment of <jats:styled-content style=\"fixed-case\"><jats:italic>A. lituratus<\/jats:italic><\/jats:styled-content> is directly regulated by serum concentrations of estradiol and progesterone, and fluctuations in these concentrations control morphological and physiological changes of this organ during different phases of the reproductive cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Research highlights<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Increases in serum concentrations of estradiol and progesterone coordinate the gestational period of <jats:styled-content style=\"fixed-case\"><jats:italic>A. lituratus<\/jats:italic><\/jats:styled-content>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Estradiol activates ER\u03b1, stimulating cell proliferation in the uterus, in addition to activating the expression of PR, which trigger the quiescence of the myometrium and stimulation of the secretion and differentiation of the endometrium.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Results showed several similarities to humans, indicating the use of <jats:styled-content style=\"fixed-case\"><jats:italic>A. lituratus<\/jats:italic><\/jats:styled-content> as an animal model in reproductive studies.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/jmor.21098","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T14:49:45Z","timestamp":1578322185000},"page":"302-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of the uterine hormonal control of the bat <scp><i>Artibeus lituratus<\/i><\/scp> during the different phases of its reproductive cycle"],"prefix":"10.1002","volume":"281","author":[{"given":"Corn\u00e9lio S.","family":"Santiago","sequence":"first","affiliation":[{"name":"Center of Biological and Health Science UFOB \u2010 Universidade Federal do Oeste da Bahia  Barreiras Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna S. S.","family":"Albernaz","sequence":"additional","affiliation":[{"name":"Center of Biological and Health Science UFOB \u2010 Universidade Federal do Oeste da Bahia  Barreiras Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata T. S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Center of Biological and Health Science UFOB \u2010 Universidade Federal do Oeste da Bahia  Barreiras Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz H. A.","family":"Guerra","sequence":"additional","affiliation":[{"name":"Department of Biology UNESP \u2013 Univ. Estadual Paulista  S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda C. A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology UFG \u2013 Universidade Federal de Goi\u00e1s  Goi\u00e2nia Goi\u00e1s Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rejane M.","family":"G\u00f3es","sequence":"additional","affiliation":[{"name":"Department of Biology UNESP \u2013 Univ. Estadual Paulista  S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Morielle\u2010Versute","sequence":"additional","affiliation":[{"name":"Department of Zoology and Botany UNESP \u2013 Univ. Estadual Paulista  S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0970-4288","authenticated-orcid":false,"given":"Sebasti\u00e3o R.","family":"Taboga","sequence":"additional","affiliation":[{"name":"Department of Biology UNESP \u2013 Univ. Estadual Paulista  S\u00e3o Jos\u00e9 do Rio Preto S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-4446","authenticated-orcid":false,"given":"Mateus R.","family":"Beguelini","sequence":"additional","affiliation":[{"name":"Center of Biological and Health Science UFOB \u2010 Universidade Federal do Oeste da Bahia  Barreiras Bahia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.04.031"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2017.03.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0531.2001.00312.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.02.018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2012.12.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD13109"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0930031"},{"key":"e_1_2_8_9_1","first-page":"188","article-title":"Progesterone action in the myometrium and decidua in preterm birth","volume":"4","author":"Blanks A. M.","year":"2012","journal-title":"Facts, Views & Visions in ObGyn"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod34.5.878"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(75)90163-X"},{"issue":"6","key":"e_1_2_8_12_1","first-page":"30","article-title":"Hormonal profile during ovarian cycle in the emballonurid female bat Taphozous kachhensis (Dobson)","volume":"4","author":"Chavhan P. R.","year":"2012","journal-title":"Academia Arena"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.12.6535"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012515400-0\/50020-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012195670-7\/50008-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901647106"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1430799"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-09352005000500002"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mambio.2009.04.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04360.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2014.07.004"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1200051"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00596"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012515400-0\/50014-2"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0220037"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(75)90186-5"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-7429.2003.tb00606.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2004.00502.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1262\/jrd.10-023T"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1080171"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4589214"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0800059"},{"issue":"4","key":"e_1_2_8_34_1","first-page":"338","article-title":"Hormonioterapia paliativa em c\u00e2ncer de mama: aspectos pr\u00e1ticos e revis\u00e3o da literatura","volume":"8","author":"Leal J. H. S.","year":"2010","journal-title":"Revista da Sociedade Brasileira de Cl\u00ednica M\u00e9dica"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3732\/ajb.90.3.388"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3161\/001.006.0109"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1040157"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.8.2963"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.suppl_3.48"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2009.01.019"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.12.4835"},{"key":"e_1_2_8_42_1","volume-title":"Mam\u00edferos do Brasil","author":"Reis N. R.","year":"2011"},{"key":"e_1_2_8_43_1","volume-title":"Inicia\u00e7\u00e3o \u00e0s t\u00e9cnicas de prepara\u00e7\u00e3o de material para o estudo e pesquisa em morfologia","author":"Ribeiro M. G.","year":"2000"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.21006"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.17-0507"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023246"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.2741\/spencer"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.31687\/saremMN.18.25.1.0.14"},{"key":"e_1_2_8_49_1","first-page":"313","article-title":"The reproduction of some Phyllostomidae (Chiroptera) from the northwestern region of the state of S\u00e3o Paulo","volume":"1","author":"Taddei V. A.","year":"1976","journal-title":"Biologia e Zoologia. Universidade de S\u00e3o Paulo"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/198104a0"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.2307\/2423327"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.11.7148"},{"key":"e_1_2_8_53_1","volume-title":"Comprehensive FREE online endocrinology book","author":"Tal R.","year":"2000"},{"key":"e_1_2_8_54_1","first-page":"41","article-title":"A speculative review of parturition in the mare","volume":"14","author":"Thorburn G. D.","year":"1993","journal-title":"Equine Veterinary Journal Supplements"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-55-5-1029"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90185-8"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0870665"},{"key":"e_1_2_8_58_1","first-page":"1637","volume-title":"Equine reproduction","author":"Vaderwall D. K.","year":"2011"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-691X(99)00273-3"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8858"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(68)90348-7"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2016.03.002"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejh.2018.2889"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.5936"},{"key":"e_1_2_8_65_1","first-page":"317","volume-title":"Biology of bats of the New World \u2013 Family Phyllostomidae. Part III","author":"Wilson D. E.","year":"1979"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.07.073"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.12.004"}],"container-title":["Journal of Morphology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjmor.21098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmor.21098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmor.21098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmor.21098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T17:46:14Z","timestamp":1694108774000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmor.21098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/jmor.21098"],"URL":"https:\/\/doi.org\/10.1002\/jmor.21098","archive":["Portico"],"relation":{},"ISSN":["0362-2525","1097-4687"],"issn-type":[{"value":"0362-2525","type":"print"},{"value":"1097-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]},"assertion":[{"value":"2019-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}